Author: Bello Gbenga
When the mesothelioma victim begins to show signs of imminent death, it is the time to for the relatives and friends to come around to say final goodbyes to their loved one. One after the other, the family members and friends might spend time with the patient, holding hands, talking to the patient, or just sitting quietly by the patient.
It can also be a time to perform any religious rituals and other activities the patient desires before he/she passes on. It is a chance for many families and friends to express their love and appreciation for the patient and for each other.
This also the time to plan for what to do after the death of the patient, so that the family will not be confused about what to during this very emotional time. If the patient is in hospice, the hospice nurse and social worker will help you. If the patient is not in hospice, talk with your doctor about it so that you will know what to do at the time of death.
These are some of the symptoms that will be seen in a dying mesothelioma cancer patient:
1- Changes in body function
•profound weakness,usually the patient cannot get out of bed and has trouble moving around in bed
•needs help with nearly everything he or she does. May be unable to change positions without help
•less and less interest in food, often with very little food and fluid intake for days
•trouble swallowing pills and medicines
•more drowsiness--the patient may doze or sleep much of the time if pain is relieved. May be restless and pick or pull at bed linens. May be hard to rouse or wake. Anxiety, fear, restlessness, and loneliness may worsen at night
•cannot concentrate, has short attention span
•confused about time, place, or people
•limited ability to cooperate with caregivers
•involuntary movement of any muscle, jerking of hands, arms, legs, or face
2- Changes in consciousness
•more sleeping during the day
•hard to wake or rouse from sleep
•confusion about time, place, or people
•restless, may pick or pull at bed linen
•may talk about things unrelated to the events or people present
•may have more anxiety, restlessness, fear, and loneliness at night
•after a period of sleepiness and confusion, may have a short time when he or she is mentally clear before going back into semi-consciousness
3- Changes in metabolism
•less interest in food -- the patient has less need for food and drink
•mouth may dry out (see the next section on changes in secretions)
•may no longer need some of his or her medicines, such as vitamins, replacement hormones, blood pressure medicines, and diuretics (unless they help make the patient more comfortable)
4- Changes in secretions
•mucus in the mouth may collect in the back of the throat (This may be a very distressing sound to hear, but doesn't usually cause discomfort to the patient.)
•secretions may thicken due to less fluid intake and build up because the patient cannot cough
.
5- Changes in circulation and temperature
•• arms and legs may feel cool to the touch as circulation slows down
•skin on arms, legs, hands, and feet may darken in color and look mottled (blotchy dark spots)
•other areas of the body may become either darker or paler
•skin may feel cold and either dry or damp
•heart rate may become fast, faint, or irregular
•blood pressure may get lower and become hard to hear
6-Changes in senses and perception
•vision may become blurry or dim
•hearing may decrease, but most patients are able to hear you even after they can no longer speak
7- Changes in breathing
•breathing may speed up and slow down due to less blood circulation and build up of waste products in the body
•mucus in the back of the throat may cause rattling or gurgling with each breath
•the patient may not breathe for periods of up 10 to 30 seconds
8- Changes in excretion
•urine may become darker and decrease in amount
•when death is near, the patient may lose control of urine and stool
Signs of irreversible death also known as "brain death"
-Cessation of breathing as the patients chest becomes still, not showing normal respiratory movements.
-Blood pressure becomes unrecordable
-Nil pulse in the blood vessels as the pulse stops
-Still immovable eyes with fixed wide gaze
-Open fixed pupils of the eyes, even in bright light
-Loss of control of bowels or bladder function as the muscles relax
After death it is all right if you sit with your loved one for a while. There is no rush to get anything done right away. Many families find this is an important time to pray or talk together and reconfirm their love for each other, as well as for the person who has passed away.
If the patient dies at home, caregivers are responsible for calling the appropriate people. Regulations or laws about who must be notified and how the body should be moved differ from one community to another. Your doctor or nurse can get this information for you. If you have a hospice or home care agency involved, call them. If you have completed funeral arrangements, calling the funeral director and doctor are usually all that you have to do.
Article Source: http://www.articlesbase.com/cancer-articles/terminal-mesothelioma-cancerhow-to-recognise-a-dying-mesothelioma-victim-1347038.html
About the AuthorBello kamorudeen.For more information on Mesothelioma go to http://www.mesotheliomacorner.blogspot.com
Saturday, October 23, 2010
Friday, October 22, 2010
Vitamin a - Possible New Drug For Mesothelioma
Author: Bello Gbenga
Vitamin A is a very important vitamin to maintaining health. Vitamin A is found in foods like carrots and it is well known for its importance in maintaining eyesight. Also recent independent research studies over the last three decades have suggested that vitamin A could possibly have an impact on managing and preventing mesothelioma.
Vitamin A has many essential functions in the human body including:
- sustenance of vision
- bone growth
- Reproduction
- Cell division
- Cell differentiation
- Helping to maintain the immune system - the body's defense against infection.
Vitamin A comes from animal sources (such as liver and whole milk) and plant sources.
Retinoids which are chemically related to vitamin A have been implicated as anti-carcinogenic. For example, according to an article published in a leading medical journal: "At the cellular level, the anti-leukemia and anti-cancer activity of retinoids is the result of three main actions, cell-differentiation, growth inhibition and apoptosis."
In a 1988 study performed by the National Cancer Institute, the dietary patterns of mesothelioma patients were compared to those of healthy individuals. According to the article, mesothelioma patients ate less homegrown, cruciferous vegetables and all vegetables combined before they were diagnosed compared to healthy patients. Cruciferous vegetables, also called Brassica Vegetables, include Arugula, Broccoli, Cauliflower, Brussels Sprouts, Cabbage, Watercress, Bok Choy, Turnip Greens, Kale, and Mustard Greens. The researchers also pointed out that carotene intake was significantly lower for the mesothelioma patients. Carotene is a precursor to vitamin A.
In this 1996 study from the Division of Epidemiology of the American Health Foundation, the investigators examined the association between dietary intake and mesothelioma by studying 94 men and women with malignant mesothelioma and 64 people without cancer. They concluded that their results provided "some justification for the hypothesis that provitamin A or beta-carotene may decrease the risk of mesothelioma. Provitamin A is any of the carotenoids that are precursors of vitamin A and can be found in fish-liver oils, egg yolk, milk products, green-leaf or yellow vegetables, and fruits.
In a study from 2002, researchers looked at mesothelioma cells in vitro (in test tubes or Petri dishes outside the body) and found that retinoic acid (the oxidized form of Vitamin A) "may lead to a decrease of mesothelioma cell local invasion." They interpreted this to mean that retinoic acid may modify how mesothelioma grows and spreads in the body. This study suggests that vitamin A levels could possibly affect the aggressiveness of mesothelioma once someone is diagnosed with the disease, thus making mesothelioma metastases unlikely.
And in 2006, Australian researchers looked at former workers and residents exposed to crocidolite (blue asbestos) in Western Australia. Their findings suggested that "people with chronically low plasma levels of retinol (the fat-soluble animal form of vitamin A found in liver and eggs) have increased risk of developing mesothelioma and lung cancer."
Will vitamin A eventually become part of conventional treatment modality for the prevention or treatment of mesothelioma? These independent studies are very preliminary, but their conclusions are intriguing. In addition, there are anecdotal reports of long-time mesothelioma survivors using vitamin A as part of their healing regiments. But first a great deal more research is needed.
Mesothelioma patients willing to add Vitamin A as part of their cancer treatment should discuss with their doctor on the use of Vitamin A before proceeding on the use.
Article Source: http://www.articlesbase.com/cancer-articles/vitamin-a-possible-new-drug-for-mesothelioma-1346995.html
About the AuthorBello kamorudeen. For more information on mesothelioma visit http://www.mesotheliomacorner.blogspot.com
Vitamin A is a very important vitamin to maintaining health. Vitamin A is found in foods like carrots and it is well known for its importance in maintaining eyesight. Also recent independent research studies over the last three decades have suggested that vitamin A could possibly have an impact on managing and preventing mesothelioma.
Vitamin A has many essential functions in the human body including:
- sustenance of vision
- bone growth
- Reproduction
- Cell division
- Cell differentiation
- Helping to maintain the immune system - the body's defense against infection.
Vitamin A comes from animal sources (such as liver and whole milk) and plant sources.
Retinoids which are chemically related to vitamin A have been implicated as anti-carcinogenic. For example, according to an article published in a leading medical journal: "At the cellular level, the anti-leukemia and anti-cancer activity of retinoids is the result of three main actions, cell-differentiation, growth inhibition and apoptosis."
In a 1988 study performed by the National Cancer Institute, the dietary patterns of mesothelioma patients were compared to those of healthy individuals. According to the article, mesothelioma patients ate less homegrown, cruciferous vegetables and all vegetables combined before they were diagnosed compared to healthy patients. Cruciferous vegetables, also called Brassica Vegetables, include Arugula, Broccoli, Cauliflower, Brussels Sprouts, Cabbage, Watercress, Bok Choy, Turnip Greens, Kale, and Mustard Greens. The researchers also pointed out that carotene intake was significantly lower for the mesothelioma patients. Carotene is a precursor to vitamin A.
In this 1996 study from the Division of Epidemiology of the American Health Foundation, the investigators examined the association between dietary intake and mesothelioma by studying 94 men and women with malignant mesothelioma and 64 people without cancer. They concluded that their results provided "some justification for the hypothesis that provitamin A or beta-carotene may decrease the risk of mesothelioma. Provitamin A is any of the carotenoids that are precursors of vitamin A and can be found in fish-liver oils, egg yolk, milk products, green-leaf or yellow vegetables, and fruits.
In a study from 2002, researchers looked at mesothelioma cells in vitro (in test tubes or Petri dishes outside the body) and found that retinoic acid (the oxidized form of Vitamin A) "may lead to a decrease of mesothelioma cell local invasion." They interpreted this to mean that retinoic acid may modify how mesothelioma grows and spreads in the body. This study suggests that vitamin A levels could possibly affect the aggressiveness of mesothelioma once someone is diagnosed with the disease, thus making mesothelioma metastases unlikely.
And in 2006, Australian researchers looked at former workers and residents exposed to crocidolite (blue asbestos) in Western Australia. Their findings suggested that "people with chronically low plasma levels of retinol (the fat-soluble animal form of vitamin A found in liver and eggs) have increased risk of developing mesothelioma and lung cancer."
Will vitamin A eventually become part of conventional treatment modality for the prevention or treatment of mesothelioma? These independent studies are very preliminary, but their conclusions are intriguing. In addition, there are anecdotal reports of long-time mesothelioma survivors using vitamin A as part of their healing regiments. But first a great deal more research is needed.
Mesothelioma patients willing to add Vitamin A as part of their cancer treatment should discuss with their doctor on the use of Vitamin A before proceeding on the use.
Article Source: http://www.articlesbase.com/cancer-articles/vitamin-a-possible-new-drug-for-mesothelioma-1346995.html
About the AuthorBello kamorudeen. For more information on mesothelioma visit http://www.mesotheliomacorner.blogspot.com
Thursday, October 21, 2010
Mesothelioma Chemotherapy-What is the Role of Alimta?
Author: Bello Gbenga
About the Author
Bello kamorudeen.For more information on mesothelioma treatment go to http://www.mesotheliomacorner.blogspot.com
Mesothelioma is a notoriously difficult asbestos related cancer to treat. Most chemotherapy drugs that have been used to treat this type of asbestos cancer have not had appreciable success in the treatment of this deadly cancer.
Among recently approved medications, Alimta stands out as having the most promise in prolonging the life of mesothelioma patients, as well as improving their quality of life.
Alimta, also known as Pemetrexed is a newer chemotherapy medication that was approved by the Food and Drug Administration (FDA) in 2005. Most times it used in combination with Cisplatin ,and Alimta is the first medication that is specifically approved for the treatment of mesothelioma and is considered to be the most effective chemotherapy treatment for pleural mesothelioma patients especially those that have advanced cancer that are not candidates for surgery.
Alimta is a multi-targeted anti-folate medication that works by blocking the enzymes required for DNA replication and cell division. During clinical trials, Alimta (used in tandem with Cisplatin) added an average of three months to the lives of malignant mesothelioma patients and also helped to reduce symptoms.
As with most cancer medications, it is imperative for patients to discuss the use of Alimta and Cisplatin with their doctor before beginning cancer treatment. An oncologist will provide facts about the effectiveness of Alimta, the administration of the medication, and the side effects patients encounter.
Cancer specialists doctors usually recommend the complimentary use of B12 supplements given intramuscularly{injection}and folic acid supplements given orally on a daily dosage (supplementation will continue for 21 days after the last dosage cycle of Alimta).
Patients are also placed on adjuvant oral steroids to help minimize side effects. Patients should inform their doctor of all other medications being taken to avoid dangerous interactions.
Alimta is given to mesothelioma patients every 21 days on an outpatient basis. Treatment consists of a 10-minute IV infusion, followed by two hours of Cisplatin. The number of cycles patients are required to receive will depend on their response to the medications and intensity of resulting side effects.
Side Effects
The side effects of Alimta are usually mild to moderate for most patients with pleural mesothelioma. Some patients may experience extreme side effects and a doctor should be informed immediately if a reaction becomes a serious problem. Side effects typically include:
•Nausea
•Vomiting
•Fatigue
•Constipation
•Diarrhea
•Loss of appetite
•Weight loss
•Tiredness
•Weakness
•Pale skin
•Headache
•Dizziness
•Confusion
•Fast heartbeat
•Difficulty falling asleep or staying asleep
•Changes in mood
•Depression
•Joint or muscle pain
•Low red blood cells count(anemia)
•Low white blood cells count(neutropenia)
•Low platelets count(thrombocytopenia)
Patients experiencing any of the following symptoms should immediately call their doctor:
•Diarrhea
•Sores in the mouth, throat, or on the lips
•Unusual bleeding or bruising
•Sore throat, fever, chills, cough, or other signs of infection
•Chest pain
•Difficulty breathing or swallowing
•Slow or difficult speech
•Weakness or numbness of an arm or leg
•Pain, burning, numbness, or tingling in the hands or feet
•Hives
•Rash
•Itching
•Decreased urination
Mesothelioma patients should avoid being near people who have colds, the flu, or other signs of illness because during chemotherapy the immune system is weakened by the chemo drugs thus making the patient very prone to "catching" infections.
Make sure to contact your doctor at once if you develop signs of an infection. Before you receive Alimta, tell your doctor if you are taking an NASAID, such as ibuprofen, naproxen, indometacin, ketoprofen, and others, these drugs tend to interact negatively with Alimta. Also before receiving Alimta, tell your doctor if you have kidney disease,liver disease,immune deficiency or the presence of excessive fluid in your lungs or in any organ in your body.
Article Source: http://www.articlesbase.com/cancer-articles/mesothelioma-chemotherapywhat-is-the-role-of-alimta-1317353.html
About the Author
Bello kamorudeen.For more information on mesothelioma treatment go to http://www.mesotheliomacorner.blogspot.com
Wednesday, October 20, 2010
Mesothelioma Chemotherapy - Do You Know the Schedule of Treatment and Common Side Effects?
Chemotherapy Schedules
How often you will receive chemotherapy will be determined by your doctor, taking into consideration factors such as the stage of your cancer, the types of drugs you receive, the anticipated toxicities of the drugs and the time necessary for your body to recover from these toxicities. The doctor may also consider whether the goal of the chemotherapy is to control the growth of the cancer, or to ease symptoms associated with the disease.
In general, chemotherapy treatment is administered in "cycles" - a "cycle" being defined as a period of treatment followed by a period of rest. This cycle allows the cancer cells to be attacked by the drugs, and then allows the body's normal cells time to recover. The combination of drugs used, the length of time to administer the drugs, how often they should be repeated and the number of cycles recommended have been analyzed very well in clinical trials.
For mesothelioma patients, the "standard" treatment is a combination of Alimta and cisplatin, administered IV, with a 10 minute infusion of Alimta followed by two hours of cisplatin, given in 21 day cycles. Modifications to this schedule may be made according to what your doctor feels is appropriate in your particular case.
The number of treatment cycles, or the length of time between the beginning and end of chemotherapy may vary, however in general, 3 to 4 cycles of treatment are given before response is evaluated; 2 to 3 cycles are considered a minimum to assess for effectiveness. After response to the treatment has been determined, the following criteria will be used to decide whether chemotherapy should continue:
• If there is shrinkage of the tumor, or the disease is kept stable, chemotherapy may be continued for as long as it can be tolerated and there is no disease progression.
• If there is continued disease progression, chemotherapy will be stopped, and the patient will be given alternative options.
The goal of setting a chemotherapy schedule is to make treatment as effective, timely and trouble-free as possible, but while the drugs are working to kill cancer cells, they may also affect healthy cells causing side effects.
Common Side Effects of Chemotherapy Includes:
-Fever of, or greater than 101 degrees
-Nausea
-Diarrhea or constipation
-Fatigue
-Tingling or numbness in the fingers or toes
-Ringing in the ears
-Bruises or rashes
-Sores in the mouth or throat
-Reduced white blood cell count {neutropenia} making you more prone to infections. For this reason your full blood count should be monitored closely.
Be sure you report all over-the-counter and prescribed medicines to your physician. Don't take aspirin unless it has been approved by your physician. Ask your pharmacist if aspirin is part of the drugs you want to purchase.
Stay away from people who have colds or the flu. Chemotherapy can compromise your immune system and lower your resistance to germs.
It is normal to feel sad, angry or afraid, however, letting these emotions get out of control can affect negatively your overall well-being. Look out for the help of family, friends, your doctor, a counselor or a support group.
Chemotherapy treatment should be a cooperative effort between you and your doctor. The interaction that takes place is important to your health. It will not only help you feel better, but will also address any potential problems with improper communication.
Patients should educate themselves about mesothelioma and treatment options and reach out to available resources to make coping with a mesothelioma diagnosis easier.
Bello kamorudeen is the author of several mesothelioma articles. For complete information on mesothelioma and its treatments visit http://www.mesotheliomacorner.blogspot.com
How often you will receive chemotherapy will be determined by your doctor, taking into consideration factors such as the stage of your cancer, the types of drugs you receive, the anticipated toxicities of the drugs and the time necessary for your body to recover from these toxicities. The doctor may also consider whether the goal of the chemotherapy is to control the growth of the cancer, or to ease symptoms associated with the disease.
In general, chemotherapy treatment is administered in "cycles" - a "cycle" being defined as a period of treatment followed by a period of rest. This cycle allows the cancer cells to be attacked by the drugs, and then allows the body's normal cells time to recover. The combination of drugs used, the length of time to administer the drugs, how often they should be repeated and the number of cycles recommended have been analyzed very well in clinical trials.
For mesothelioma patients, the "standard" treatment is a combination of Alimta and cisplatin, administered IV, with a 10 minute infusion of Alimta followed by two hours of cisplatin, given in 21 day cycles. Modifications to this schedule may be made according to what your doctor feels is appropriate in your particular case.
The number of treatment cycles, or the length of time between the beginning and end of chemotherapy may vary, however in general, 3 to 4 cycles of treatment are given before response is evaluated; 2 to 3 cycles are considered a minimum to assess for effectiveness. After response to the treatment has been determined, the following criteria will be used to decide whether chemotherapy should continue:
• If there is shrinkage of the tumor, or the disease is kept stable, chemotherapy may be continued for as long as it can be tolerated and there is no disease progression.
• If there is continued disease progression, chemotherapy will be stopped, and the patient will be given alternative options.
The goal of setting a chemotherapy schedule is to make treatment as effective, timely and trouble-free as possible, but while the drugs are working to kill cancer cells, they may also affect healthy cells causing side effects.
Common Side Effects of Chemotherapy Includes:
-Fever of, or greater than 101 degrees
-Nausea
-Diarrhea or constipation
-Fatigue
-Tingling or numbness in the fingers or toes
-Ringing in the ears
-Bruises or rashes
-Sores in the mouth or throat
-Reduced white blood cell count {neutropenia} making you more prone to infections. For this reason your full blood count should be monitored closely.
Be sure you report all over-the-counter and prescribed medicines to your physician. Don't take aspirin unless it has been approved by your physician. Ask your pharmacist if aspirin is part of the drugs you want to purchase.
Stay away from people who have colds or the flu. Chemotherapy can compromise your immune system and lower your resistance to germs.
It is normal to feel sad, angry or afraid, however, letting these emotions get out of control can affect negatively your overall well-being. Look out for the help of family, friends, your doctor, a counselor or a support group.
Chemotherapy treatment should be a cooperative effort between you and your doctor. The interaction that takes place is important to your health. It will not only help you feel better, but will also address any potential problems with improper communication.
Patients should educate themselves about mesothelioma and treatment options and reach out to available resources to make coping with a mesothelioma diagnosis easier.
Bello kamorudeen is the author of several mesothelioma articles. For complete information on mesothelioma and its treatments visit http://www.mesotheliomacorner.blogspot.com
Monday, October 18, 2010
Mesothelioma Prognosis Why Do Some Patients Survive Longer?
By: Bello Kamorudeen
Author Resource:-> Bello Kamorudeen.For more information on mesothelioma treatments and clinical trials go to http://www.mesotheliomacorner.blogspot.com
There have been some few patients who have survived far beyond the usual one year prognosis for most mesothelioma victims and a handful that have even been cured, with no trace of the aggressive cancer several years after treatment (though recurrence is always possible).
Many medical experts are baffled by this observation and for most of the time they are yet to find a real scientific basis to explain why some mesothelioma patients survive and others do not.
There seems to be one common factor amongst those that have survived the disease for longer times the immune system. Studies of those who have either survived or been cured of the disease reveal that most of these patients participated in some sort of therapy that enhanced their immune system. Some treatments included clinical trials in immunology while others involved alternative therapies dealing with the immune system.
A number of mesothelioma survivors have posted their stories on the Internet and have spoken to patients and their families with the hope of providing a brighter outlook for their future. These same survivors have also presented their cases to doctors and researchers. The most outspoken of these individuals is Paul Kraus, an Australian mesothelioma survivor. Kraus was diagnosed with abdominal/ peritoneal mesothelioma in 1997, a form of the disease that is tougher to treat than the more common pleural mesothelioma. Kraus worked in a factory 35 years earlier where he was exposed him to blue (crocidolite) asbestos.
Upon his diagnosis, Kraus changed his diet (he s now a vegetarian), added many vitamins and supplements to his daily routine, began juicing, and tried a treatment known as ozone therapy. Kraus explains, They took blood out of a vein, used an ozone machine to add ozone (a molecule composed of three oxygen atoms) to the blood and reintroduced it into my body through a drip. The rationale for that was that cancer does not like an oxygenated environment. The research in putting the protocol together took a lot of time, but in the long run, Kraus believes the combination of all these treatments stabilized his mesothelioma. Today, tests show he still has the disease and his body is a bit weaker than it was, but he has no pain and his doctors tell him he has many more years to live. Kraus stresses the fact that he is not the only mesothelioma survivor.
He has cited the case of a man diagnosed 14 years ago at age 58 (no name given) who had a chest wall resection after diagnosis and has had no symptoms or recurrence since. His doctors believe there was moderate host inflammatory response and that spontaneous regression may be an immune mediated phenomenon in other words, his immune system played a role in his survival.
Another survivor, Rhio O Connor who recently published a book about his fight with mesothelioma has lived with the disease for seven years. He opted against the conventional methods of treatment like surgery, chemotherapy and radiotherapy. Instead, with the help of several medical physicians, he developed a regimen that included 100 supplements per day, changed his diet drastically, and now practices what he calls mind body medicine (such as non stress techniques like meditation). In his book, he recommends a variety of alternatives to traditional medicines and treatments.
All mesothelioma patients should be encouraged to participate in clinical trials especially those that are trying out new methods of boosting the immune system.
Author Resource:-> Bello Kamorudeen.For more information on mesothelioma treatments and clinical trials go to http://www.mesotheliomacorner.blogspot.com
Saturday, October 16, 2010
Mesothelioma Blood Test Mesomark Test
By : Bello Kamorudeen
The reason for high death rates among mesothelioma patients is the aggressive nature of the disease and the inability to diagnose it until it is well advanced. Because mesothelioma symptoms do not show up until about 40 50 years after exposure to asbestos, most cases at the time of diagnosis have already reached Stage III or IV. As a result, mesothelioma treatment options are often more palliative than curative.
However, the ability to diagnose the disease at an earlier time would certainly result in a better prognosis for mesothelioma patients. That ability is now present in the form of a mesothelioma blood test known as Mesomark. Developed by Fujirebio Diagnostics Inc. of Malvern, Pennsylvania, a leader in the field of oncology testing, the test measures the amount of a particular biomarker in human serum.
The test was first released in Australia in March 2005 and distribution expanded to Europe just a few months later. Food and Drug Administration approval for the blood test was received nearly two years later in January 2007.
Testing for Mesothelioma
Mesomark is an easily performed blood test that uses an enzyme linked immunosorbent assay to measure the amount of Soluble Mesothelin Related Peptides (SMRP) in human serum. SMRP is a biomarker that is produced by mesothelioma cells, and this biomarker may be elevated in the serum of patients who have mesothelioma. The detection of the biomarker through a blood test can help attain an early diagnosis, resulting in more treatment options and a better prognosis for patients.
Mesomark is what is referred to as an in vitro test. In this test, the blood that is drawn from the patient is sent to a laboratory to measure the level of SMRP. This is performed by using monoclonal antibodies that are known to specifically bind to SMRP. Measuring the amount of bound antibodies in the blood indicates the amount of SMRP, and certain levels indicate the presence of mesothelioma. In addition to detecting the presence of mesothelioma in yet to be diagnosed patients, the Mesomark blood test may also be used to monitor the success of treatments in patients who have already been diagnosed with the disease.
These tests will also help determine the next course of treatment.
The Mesomark blood test has NOT yet been approved for the early diagnosis of mesothelioma.
This test has been approved as a Humanitarian Use Device (HUD), meaning that physicians must follow certain procedures to qualify their patients for testing. Once the physician is certified, informational brochures will be sent to be distributed to each applicable patient.
Those wishing to take part in Mesomark testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.
The costs associated with the Mesomark blood test may not be covered under health insurance, therefore, you may be required to pay all or part of the costs out of pocket. It is recommended that you check with your insurance carrier to determine whether coverage is available under your policy.
Author: Bello kamorudeen.For complete information on mesothelioma diagnosis visit http://www.mesotheliomacorner.blogspot.com
The reason for high death rates among mesothelioma patients is the aggressive nature of the disease and the inability to diagnose it until it is well advanced. Because mesothelioma symptoms do not show up until about 40 50 years after exposure to asbestos, most cases at the time of diagnosis have already reached Stage III or IV. As a result, mesothelioma treatment options are often more palliative than curative.
However, the ability to diagnose the disease at an earlier time would certainly result in a better prognosis for mesothelioma patients. That ability is now present in the form of a mesothelioma blood test known as Mesomark. Developed by Fujirebio Diagnostics Inc. of Malvern, Pennsylvania, a leader in the field of oncology testing, the test measures the amount of a particular biomarker in human serum.
The test was first released in Australia in March 2005 and distribution expanded to Europe just a few months later. Food and Drug Administration approval for the blood test was received nearly two years later in January 2007.
Testing for Mesothelioma
Mesomark is an easily performed blood test that uses an enzyme linked immunosorbent assay to measure the amount of Soluble Mesothelin Related Peptides (SMRP) in human serum. SMRP is a biomarker that is produced by mesothelioma cells, and this biomarker may be elevated in the serum of patients who have mesothelioma. The detection of the biomarker through a blood test can help attain an early diagnosis, resulting in more treatment options and a better prognosis for patients.
Mesomark is what is referred to as an in vitro test. In this test, the blood that is drawn from the patient is sent to a laboratory to measure the level of SMRP. This is performed by using monoclonal antibodies that are known to specifically bind to SMRP. Measuring the amount of bound antibodies in the blood indicates the amount of SMRP, and certain levels indicate the presence of mesothelioma. In addition to detecting the presence of mesothelioma in yet to be diagnosed patients, the Mesomark blood test may also be used to monitor the success of treatments in patients who have already been diagnosed with the disease.
These tests will also help determine the next course of treatment.
The Mesomark blood test has NOT yet been approved for the early diagnosis of mesothelioma.
This test has been approved as a Humanitarian Use Device (HUD), meaning that physicians must follow certain procedures to qualify their patients for testing. Once the physician is certified, informational brochures will be sent to be distributed to each applicable patient.
Those wishing to take part in Mesomark testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.
The costs associated with the Mesomark blood test may not be covered under health insurance, therefore, you may be required to pay all or part of the costs out of pocket. It is recommended that you check with your insurance carrier to determine whether coverage is available under your policy.
Author: Bello kamorudeen.For complete information on mesothelioma diagnosis visit http://www.mesotheliomacorner.blogspot.com
Immunotherapy -A New Way of Fighting Mesotheloma
Conventional cancer treatments like radiotherapy and chemotherapy are more widely used to treat mesothelioma, but alternative treatments such as immunotherapy are becoming more and popular too. Other therapies such as immunotherapy provide the patient with additional options for the control of symptoms. While immunology does not yet offer a cure for mesothelioma, researchers continue to experiment with the treatment in hopes of achieving better results.
Immunotherapy involves the use and manipulation of a patient's own immune system to help them fight diseases to which the immune system would not normally respond.
In the case of mesothelioma and other types of asbestos cancer, the patient's immune response does not typically react or destroy cancer cells for one very important reason: a normal healthy immune system does not recognize cancer cells as foreign cells so it does not destroy them.
Immunotherapy is a type of treatment that tricks the immune system into believing that cancer cells are foreign. When this type of treatment is administered to cancer patients, the immune system can be made to destroy cancer cells, while leaving normal healthy cells unharmed.
Treating mesothelioma patients with immunotherapy relies on helping the body's immune system to recognize the difference between healthy cells and cells that have become cancerous.
To understand how immunotherapy works, it is first important to understand how the immune system differentiates between normal body cells and foreign cells. The immune system does this by recognizing and reacting to antigens. Antigens are molecules that are present on the surface of all cells, whether human, bacterial, or viral. A normal immune system can react to and destroy cells that produce antigens that are foreign, but cannot react to cells that produce "self" antigen (an antigen produced by the body).
Immunotherapy, therefore, is geared towards making the immune system recognize antigens on cancer cells as being foreign, allowing the immune system to destroy those cells. There two ways by which immunotherapy can be used:1]Active immunity and 2]Passive immunity
Active Immunotherapy for Mesothelioma
Active immunotherapy treatments stimulate the immune system to fight disease. Vaccines, for example, are a type of active immunotherapy. Cancer vaccines are slightly different in that they are designed to fight diseases that already exist in the body, whereas most other vaccines are administered to prevent disease.
Mesothelioma vaccines may be created by removing cancer cells from a mesothelioma patient. This is usually done in a laboratory by using either whole cancer cells or antigens removed from cells. The cells or antigens are modified in a laboratory so they can be recognized by the patient's immune system and are then injected back into the patient.
Active immunotherapy treatments for mesothelioma are highly specific treatments made with cells from the patient's own body. Thus, a different vaccine is created for each patient who receives active immunotherapy treatment.
Passive Immunotherapy Treatment for Mesothelioma
Passive immunotherapy treatments are those which use components that are created outside the body. These types of treatments differ from active immunotherapy in that passive treatments do not attempt to force the immune system to actively destroy cancer cells.
One example of a passive immunotherapy treatment is monoclonal antibody therapy, which is currently the most widely used immunotherapy for treating cancer. Antibodies are molecules the immune system produces to help fight infections. In an immune system that is functioning normally, antibodies are produced that recognize and bind to foreign antigens present on foreign cells, which effectively targets foreign cells for destruction by other parts of the immune system.
Monoclonal antibody therapy involves removing cancer cells from a patient, which are then grown together in a laboratory with other cells that produce antibodies in response to antigens on the cancer cells. During this process, identical antibodies are produced that recognize the same antigen (hence the termed monoclonal).
The next stage of the treatment involves injecting the patient with the monoclonal antibodies. Once inside the body, the antibodies recognize and bind to tumor cells, as the tumor cells possess the specific kind of antigen that the antibodies were created to identify. If the cancer treatment is successful, the immune system will recognize the monoclonal antibodies and destroy the cancer cells.
Immunotherapy is however still largely in experimental stages of different clinical trials all over the world and most of them are yet to be approved for general use, so if any mesothelioma patient wants to benefit from immunotherapy they must participate in relevant clinical trials.
Bello kamorudeen.For more information on mesothelioma treatment visit http://www.mesotheliomacorner.blogspot.com
Immunotherapy involves the use and manipulation of a patient's own immune system to help them fight diseases to which the immune system would not normally respond.
In the case of mesothelioma and other types of asbestos cancer, the patient's immune response does not typically react or destroy cancer cells for one very important reason: a normal healthy immune system does not recognize cancer cells as foreign cells so it does not destroy them.
Immunotherapy is a type of treatment that tricks the immune system into believing that cancer cells are foreign. When this type of treatment is administered to cancer patients, the immune system can be made to destroy cancer cells, while leaving normal healthy cells unharmed.
Treating mesothelioma patients with immunotherapy relies on helping the body's immune system to recognize the difference between healthy cells and cells that have become cancerous.
To understand how immunotherapy works, it is first important to understand how the immune system differentiates between normal body cells and foreign cells. The immune system does this by recognizing and reacting to antigens. Antigens are molecules that are present on the surface of all cells, whether human, bacterial, or viral. A normal immune system can react to and destroy cells that produce antigens that are foreign, but cannot react to cells that produce "self" antigen (an antigen produced by the body).
Immunotherapy, therefore, is geared towards making the immune system recognize antigens on cancer cells as being foreign, allowing the immune system to destroy those cells. There two ways by which immunotherapy can be used:1]Active immunity and 2]Passive immunity
Active Immunotherapy for Mesothelioma
Active immunotherapy treatments stimulate the immune system to fight disease. Vaccines, for example, are a type of active immunotherapy. Cancer vaccines are slightly different in that they are designed to fight diseases that already exist in the body, whereas most other vaccines are administered to prevent disease.
Mesothelioma vaccines may be created by removing cancer cells from a mesothelioma patient. This is usually done in a laboratory by using either whole cancer cells or antigens removed from cells. The cells or antigens are modified in a laboratory so they can be recognized by the patient's immune system and are then injected back into the patient.
Active immunotherapy treatments for mesothelioma are highly specific treatments made with cells from the patient's own body. Thus, a different vaccine is created for each patient who receives active immunotherapy treatment.
Passive Immunotherapy Treatment for Mesothelioma
Passive immunotherapy treatments are those which use components that are created outside the body. These types of treatments differ from active immunotherapy in that passive treatments do not attempt to force the immune system to actively destroy cancer cells.
One example of a passive immunotherapy treatment is monoclonal antibody therapy, which is currently the most widely used immunotherapy for treating cancer. Antibodies are molecules the immune system produces to help fight infections. In an immune system that is functioning normally, antibodies are produced that recognize and bind to foreign antigens present on foreign cells, which effectively targets foreign cells for destruction by other parts of the immune system.
Monoclonal antibody therapy involves removing cancer cells from a patient, which are then grown together in a laboratory with other cells that produce antibodies in response to antigens on the cancer cells. During this process, identical antibodies are produced that recognize the same antigen (hence the termed monoclonal).
The next stage of the treatment involves injecting the patient with the monoclonal antibodies. Once inside the body, the antibodies recognize and bind to tumor cells, as the tumor cells possess the specific kind of antigen that the antibodies were created to identify. If the cancer treatment is successful, the immune system will recognize the monoclonal antibodies and destroy the cancer cells.
Immunotherapy is however still largely in experimental stages of different clinical trials all over the world and most of them are yet to be approved for general use, so if any mesothelioma patient wants to benefit from immunotherapy they must participate in relevant clinical trials.
Bello kamorudeen.For more information on mesothelioma treatment visit http://www.mesotheliomacorner.blogspot.com
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