Thursday, November 4, 2010

How to Choose the Best Mesothelioma Clinical Trial

By Bello Kamorudeen

You can find out about good mesothelioma clinical trials in
different ways. You can enter for clinical trials do so after
hearing about them from your doctor. You can also actively look
for clinical trials on the Internet or in other places, hoping
to find more options for treatment. Some clinical trials are
advertised directly to patients.

Information about mesothelioma cancer resources can be obtained
from several resources. These resources can be divided into 2
main types: clinical trials lists and clinical trials matching
services.

1- Clinical trial lists

These sources give you the names and descriptions of clinical
trials of new treatments. If there is a study you are interested
in, you will probably be able to find it in a list. The list
will often include a description of the study, the criteria for
patient eligibility, and a contact person. If you (or your
health care providers) are willing and able to read through
descriptions of all the studies listed for your cancer type,
then a list may be all you need. Some organizations that provide
lists can help you narrow the list a little, according to the
kind of treatment you are looking for (chemotherapy,
immunotherapy, radiation therapy, etc.) and the stage of your
cancer.

2- Clinical trials matching services

Over the past few years, several organizations have developed
computer-based systems to match patients with studies they may
be eligible for. This service is often offered online.

Each may differ somewhat in how it works. Some of the services
allow you to search for clinical trials without registering at
the site. If you have to register, they usually assure you that
your information will be kept confidential. Either way, you will
probably have to enter certain details, such as the type of
cancer, the stage of the disease, and any previous treatments
you may have had. When given this information, these systems can
find clinical trials for which you may be eligible, and save you
the time and effort of reading descriptions of studies that are
not relevant to you. Some groups also allow you to subscribe to
mailing lists so that you are informed as new studies open up.

Although they are usually free to users, most clinical trial
matching services get paid for listing studies or get a finder's
fee from those running the studies when someone enrolls. Because
of this, there may be some differences in the way they rank the
studies, or the order in which they present the studies to you.

Because different services work differently, be sure you
understand how the service you are looking at operates. Ask the
following questions. (Note that the answers do not necessarily
mean that the service is not worth using.)
•Is there a fee for using the service?
•Do I have to register to use the service?
•Does the service keep my information confidential?
•Where does the service get its list of clinical trials?
•Does the service rank the studies in any particular order? Is
this based on fees they get?
•Can I contact the service through the Internet or by
telephone?

Examples of clinical trials matching services are:

1- The American Cancer Society Clinical Trials Matching
Service:
The American Cancer Society helps patients find high quality
care in clinical trials that best match their medical needs and
personal preferences, while helping researchers study more
effective treatments for future patients

The TrialCheck® database, developed and maintained by the
Coalition of Cancer Cooperative Groups, is a comprehensive
database that includes the Coalition, National Cancer Institute,
and industry trials. To our knowledge, this is the most complete
matching database of cancer clinical trials available.

The clinical trials information provided by the American Cancer
Society is not biased in any way. It is updated every day, as is
the contact information that allows patients to get in touch
with the doctors and nurses at cancer centers running each of
the studies.
You can access the TrialCheck at www.cancer.org (click on "Find
a Clinical Trial") or through a toll-free number,
1-800-303-5691.

2- The National Cancer Institute (NCI) sponsors most
government-funded cancer clinical trials. The NCI has a list of
active studies (those currently enrolling patients), as well as
some privately funded studies. You can find the list on their
Web site at www.cancer.gov/clinicaltrials or by calling
1-800-4-CANCER (1-800-422-6237). You can search the list by the
type and stage of cancer, by the type of study (for example,
treatment or prevention), or by zip code.

3- The National Institutes of Health (NIH) has an even larger
database of clinical trials at www.clinicaltrials.gov, but not
all of these are cancer studies.

4- EmergingMed provides a free and confidential matching and
referral service for cancer patients looking for clinical trials
at www.emergingmed.com, or you can call 1-877-601-8601.

5- CenterWatch (www.centerwatch.com) is a publishing and
information services company that keeps a list of both
industry-sponsored and government-funded clinical trials for
cancer and other diseases.

6- Private companies, such as pharmaceutical or biotechnology
firms, may list the studies they are sponsoring on their Web
sites or offer toll-free numbers so you can call and ask about
them. Some of these firms also offer matching systems for the
studies they sponsor. This can be helpful if you are interested
in research on a particular experimental treatment and know
which company is developing it.

About the Author: Bello kamorudeen.For more information on
Mesothelioma treatment go to
http://www.mesotheliomacorner.blogspot.com

Source: http://www.isnare.com

Permanent Link:
http://www.isnare.com/?aid=422891&ca=Cancer+Survival

Wednesday, November 3, 2010

Long Time Mesothelioma Survivors -What Do They Have in Common?

By Bello Kamorudeen

Paul Kraus is one of the long-term survivors of malignant
mesothelioma, there are many others and one thing they all have
in common to all of them is the fact that they all focused most
of their treatment on steps to improve or enhance their immune
system. Some used alternative or complimentary therapies (with
guidance from licensed clinicians) while others participated in
clinical trials of immune therapy.

So does the immune system play a significant role in the
control malignant mesothelioma? The experience of Paul Kraus and
other long-term malignant mesothelioma survivors gives a lot of
credit to the fact that the immune system is indeed very
important in the management of malignant mesothelioma.

In quite a number of people with pleural mesothelioma that
survived the cancer for a long time, their medical histories
have shown that their immune system may have played a major role
in their extremely long survival.

In 1986, an article appeared in a medical journal that
discussed this very issue of malignant mesothelioma and
immunity.(1) This research focused on the immune responses of
118 healthy people compared to 20 patients with malignant
mesothelioma and 375 long-term asbestos workers who were
cancer-free.

The researchers wanted to know if there were any measurable
differences in the immune responses of the mesothelioma
patients. Their findings demonstrated a relationship between the
immune system and malignant mesothelioma. For example:

• The number of total T (T11+) and T-helper (T4+) cells were
normal in asbestos workers with cancer, but were significantly
reduced in patients with mesothelioma. T cells orchestrate,
regulate and coordinate the overall immune response.

• Most patients with mesothelioma had a profound deficiency
in Natural Killer cell (NK) activity which is suggestive of the
role the immune system plays in the control of malignant
mesothelioma. NK cells are a type of lethal lymphocyte that
target tumor cells and protect against a wide variety of
infectious microbes.

In the discussion section of the report, the researchers
stated:
“These findings led us to speculate that biological phenomena
generally categorized as chronic immunosuppression associated
with the presence of asbestos fibers in the exposed workers may
have caused the eventual breakdown of the host’s surveillance
system and the onset of neoplasm [malignant mesothelioma].”

In other words, the researchers are suggesting that malignant
mesothelioma may result from immune suppression. If this is true
it would provide the biological basis for the role that the
immune system and immune boosting approaches may play in the
management of malignant mesothelioma.

Another example of a long time survivor of mesothelioma is
James O’Connor.In October 2001, sixty-one year old James Rhio
O'Connor ("Rhio") was diagnosed with pleural mesothelioma caused
by his exposure to asbestos when he was younger. His was given
less than a year to live.

His tumor was not operable because the tumor was too close to
his spinal cord chemo was also not an option because at the
stage of his tumor chemo would not have been of any major help
to him, it could not give any significant elongation to his life
span. He was basically told to prepare for imminent death in a
polite manner.

To soften this message, the doctor also recommended that Rhio
take his wife on a cruise and then start hospice care upon his
return. Rhio rejected the idea. He was determined to survive
this cancer. Working with professional clinicians, he formulated
a regimen of over 100 supplements a day, changed his diet,
practiced mind-body medicine, most of these treatments were
aimed at boosting the immune system, and he relied on his own
discipline to see him through the difficult times ahead.

Rhio survived for 7 ½ more years through his determination,
knowledge, inexorable spirit, belief in something greater than
himself, and the ability to make tough choices -qualities that
spell success in any endeavor. Rhio passed away on July 11,
2009. He was 69 years old.
Rhio was often asked how he was able to manage his mesothelioma
or "Mr. Meso" as he called it.

To answer these questions and help and inspire others, Rhio
wrote a book called "They Said Months, I Chose Years: A
Mesothelioma Survivor's Story." In this book Rhio discusses what
he did to live his life with "Mr. Meso" and much of the science
behind his decisions. In his book he cites nearly one hundred
medical articles that support the concept of using nutrition to
help manage a chronic disease like cancer. Rhio's inspirational
life and book reminds us that there may be other ways to manage
cancer and extend life beyond the conventional methods of
surgery, chemotherapy and radiotherapy.

About the Author: Bello Kamorudeen.For more information about
Mesothelioma prognosis go to
http://www.mesotheliomacorner.blopgspot.com

Source: http://www.isnare.com

Permanent Link:
http://www.isnare.com/?aid=423736&ca=Cancer+Survival

Tuesday, November 2, 2010

Long Time Mesothelioma Survivors -What Do They Have in Common?

By Bello Kamorudeen

Paul Kraus is one of the long-term survivors of malignant
mesothelioma, there are many others and one thing they all have
in common to all of them is the fact that they all focused most
of their treatment on steps to improve or enhance their immune
system. Some used alternative or complimentary therapies (with
guidance from licensed clinicians) while others participated in
clinical trials of immune therapy.

So does the immune system play a significant role in the
control malignant mesothelioma? The experience of Paul Kraus and
other long-term malignant mesothelioma survivors gives a lot of
credit to the fact that the immune system is indeed very
important in the management of malignant mesothelioma.

In quite a number of people with pleural mesothelioma that
survived the cancer for a long time, their medical histories
have shown that their immune system may have played a major role
in their extremely long survival.

In 1986, an article appeared in a medical journal that
discussed this very issue of malignant mesothelioma and
immunity.(1) This research focused on the immune responses of
118 healthy people compared to 20 patients with malignant
mesothelioma and 375 long-term asbestos workers who were
cancer-free.

The researchers wanted to know if there were any measurable
differences in the immune responses of the mesothelioma
patients. Their findings demonstrated a relationship between the
immune system and malignant mesothelioma. For example:

• The number of total T (T11+) and T-helper (T4+) cells were
normal in asbestos workers with cancer, but were significantly
reduced in patients with mesothelioma. T cells orchestrate,
regulate and coordinate the overall immune response.

• Most patients with mesothelioma had a profound deficiency
in Natural Killer cell (NK) activity which is suggestive of the
role the immune system plays in the control of malignant
mesothelioma. NK cells are a type of lethal lymphocyte that
target tumor cells and protect against a wide variety of
infectious microbes.

In the discussion section of the report, the researchers
stated:
“These findings led us to speculate that biological phenomena
generally categorized as chronic immunosuppression associated
with the presence of asbestos fibers in the exposed workers may
have caused the eventual breakdown of the host’s surveillance
system and the onset of neoplasm [malignant mesothelioma].”

In other words, the researchers are suggesting that malignant
mesothelioma may result from immune suppression. If this is true
it would provide the biological basis for the role that the
immune system and immune boosting approaches may play in the
management of malignant mesothelioma.

Another example of a long time survivor of mesothelioma is
James O’Connor.In October 2001, sixty-one year old James Rhio
O'Connor ("Rhio") was diagnosed with pleural mesothelioma caused
by his exposure to asbestos when he was younger. His was given
less than a year to live.

His tumor was not operable because the tumor was too close to
his spinal cord chemo was also not an option because at the
stage of his tumor chemo would not have been of any major help
to him, it could not give any significant elongation to his life
span. He was basically told to prepare for imminent death in a
polite manner.

To soften this message, the doctor also recommended that Rhio
take his wife on a cruise and then start hospice care upon his
return. Rhio rejected the idea. He was determined to survive
this cancer. Working with professional clinicians, he formulated
a regimen of over 100 supplements a day, changed his diet,
practiced mind-body medicine, most of these treatments were
aimed at boosting the immune system, and he relied on his own
discipline to see him through the difficult times ahead.

Rhio survived for 7 ½ more years through his determination,
knowledge, inexorable spirit, belief in something greater than
himself, and the ability to make tough choices -qualities that
spell success in any endeavor. Rhio passed away on July 11,
2009. He was 69 years old.
Rhio was often asked how he was able to manage his mesothelioma
or "Mr. Meso" as he called it.

To answer these questions and help and inspire others, Rhio
wrote a book called "They Said Months, I Chose Years: A
Mesothelioma Survivor's Story." In this book Rhio discusses what
he did to live his life with "Mr. Meso" and much of the science
behind his decisions. In his book he cites nearly one hundred
medical articles that support the concept of using nutrition to
help manage a chronic disease like cancer. Rhio's inspirational
life and book reminds us that there may be other ways to manage
cancer and extend life beyond the conventional methods of
surgery, chemotherapy and radiotherapy.

About the Author: Bello Kamorudeen.For more information about
Mesothelioma prognosis go to
http://www.mesotheliomacorner.blopgspot.com

Source: http://www.isnare.com

Permanent Link:
http://www.isnare.com/?aid=423736&ca=Cancer+Survival

Monday, November 1, 2010

Mesothelioma Support Groups-How to Find the Best One For You

By Bello Kamorudeen

When you are faced with a diagnosis of mesothelioma cancer
there are many resources are available for you and your family
to benefit. You can seek for support from family and friends, as
well as from health professionals, support groups, or your place
of worship. Asking for support is one way you can feel in
control of what's going on in your life, your need for support
is not a sign of weakness.

You feel lonely and abandoned. You may loose your desire to
continue living . If your are not getting the much needed
support from your friends and family then find others who can
support you. There are probably others in your community who
need your companionship as much as you need theirs. The mutual
support of others with cancer might also be a source of
comfort.You will probably need the support of different support
groups to help you cope with the diagnosis of mesothelioma
cancer.

What are different types of support groups?

There are different types and formats for support groups, there
are individual, group counseling and support groups. Some
support groups are formal and focus on learning about cancer or
dealing with feelings. There are also less formal and more
social groups. Some groups consist mainly of people with cancers
or only caregivers, while others include spouses, family
members, or friends. Other groups focus on certain types of
cancer or stages of disease like mesothelioma cancer. Some
groups have their meetings over a number of weeks while some
others meet over a longer period of time. Some programs no
longer accept new members while other groups are still open to
new members.

Health professionals (a social worker, nurse, or other licensed
professional), trained facilitators, or a group member may lead
the group. The leader of a group should have some type of
training before taking charge of a support group.

Telephone counseling groups

For those who cannot attend meetings or appointments,
counseling over the telephone is offered by organizations such
as Cancer Care, Inc. Some people may find online support groups
helpful because they like the privacy. It may be comforting to
chat with other people facing situations much like yours. But
keep in mind that chat rooms and message boards are not the best
source of cancer information, especially if they are not
monitored by trained professionals or experts.

No matter what kind of group it is, everyone taking part should
feel comfortable in the group and with the facilitator. If you
have any fears or uncertainties before entering a group, try to
discuss them with the group's facilitator ahead of time.

Along with support programs, other means of support may be
available in your community such as:
•Home health nursing services
•Social services, such as counseling and financial aid
•Nutrition services that provide meals or allow you to talk
with a registered dietitian
•Rehabilitation services provided by physical and occupational
therapists
•Spiritual services from chaplains or religious figures in the
community
Support in any form allows you to talk about your feelings and
develop skills to cope with the changes taking place in your
life. Some studies have found that people who go to support
groups have an improved quality of life, including better sleep
and appetite.

Self-help groups

Self-help groups are most often run by non-professionals who
have been through the same kinds of problems or crises. The
people in these groups can relate to your experience firsthand
and often have treatment-related tips and advice that may help
you. For example, they may offer a home remedy that helped with
their nausea, or know where to get the best prices on wigs and
turbans. If their family members are not in the group, patients
are free to express exactly how they feel. Family members can
also benefit from sharing their feelings, fears, and anxieties
with other families affected by mesothelioma cancer.

Self-help groups also give people recovering or who are long
term survivors of mesothelioma cancer help others with the
cancer. With some training, many people with cancer have found
that helping others makes them feel better about themselves.
They may go on to become group counselors or facilitators.

Choosing when to take part in a support group is important.
Some find it difficult to join a support group when they are
first diagnosed. The stories that other patients may share,
after months or even years of treatment, can be overwhelming and
upsetting. If you try a group and it doesn't feel right, you may
want to try again later or try another group.

Religion

Religion can be a source of strength for some people. Some find
new faith when diagnosed with cancer. Others find their cancer
experience strengthens their existing faith or their faith gives
them newfound strength and hope. Others who have never had
strong religious beliefs may not feel an urge to turn to
religion at this time. A minister, rabbi, other leader of your
faith, or a trained pastoral counselor can help you find
spiritual support. Some members of the clergy are specially
trained to minister to people with cancer and their families.
Some hospitals also have chaplains available.

Ask your health care team about the resources available at your
hospital. You can also contact your American Cancer Society to
find out about sources of support that are available in your
community.

About the Author: Bello Kamorudeen. For more information on
mesothelioma cancer visit
http://www.mesotheliomacorner.blogspot.com

Source: http://www.isnare.com

Permanent Link:
http://www.isnare.com/?aid=423982&ca=Cancer+Survival

Sunday, October 31, 2010

How to Cope With the Stress of Mesothelioma Chemotherapy

By Bello Kamorudeen

Chemotherapy can be a grueling experience for most mesothelioma patients, most of the anti cancer drugs have terrible side effects that you will experience during the course of the therapy. These following steps will help you cope with the stress of chemotherapy:

-Focus on the goals of your treatment in your mind. This will help you keep a positive attitude on days when the going gets rough.

-Try and eat good food, though in little and moderate quantities, your body needs all the necessary food nutrients to rebuild tissues and remain strong

-Learn as much as you want to know about mesothelioma cancer and its treatment. This will help you to cope better with the fear of the unknown and increase your feeling of control.

-Keep a journal or diary while you're being treated. A record of your activities and thoughts can help you understand the feelings you have as you go through treatment. It can also help you highlight questions you need to ask your doctor or nurse. You also can use your journal to record the side effects. This will help you when you talk about them with your doctor and nurse. You can write down the steps you take to cope with side effects and how well those steps work, too. That way, you’ll know which methods worked best for you in case you have the same side effects again.

-Do not over exert yourself physically; you need to take things easy as your strength will be depleted by the effects of the powerful drugs that you are taking, so try to get as much rest as you can. Let the small stuff slide and only do the things that are most important to you.

-Try new hobbies and learn new skills.

-Exercise if you can and if your doctor says you can. Exercise helps to make you feel better about yourself, help you get rid of tension or anger, and build your appetite.

-Devise means of coping with stress and relaxing. There are simple techniques that you can practice that can help you cope with stress and help you relax. You should discuss with your doctor before you start using these techniques, especially if you have lung problems.

These are some of the technique that can help you deal with stress and relax:

•Lie down in a quiet room.

•Take a slow, deep breath.

•As you breathe in, tense a muscle or group of muscles. For example, clench your teeth or stiffen your arms or legs.

•Keep your muscles tense for a second or 2 while holding your breath.

•Then breathe out, release the tension, and let your body relax completely.

•Repeat the process with another muscle or muscle group.

Another way to do this is called progressive relaxation. You work your way up your body starting with the toes of one foot. Contract then relax all the muscles of one leg. Do the same with the other leg. Work your way up your body, contracting then relaxing each of the muscle groups in your body, including those in your neck and face. Remember to hold your breath while briefly contracting your muscles and to breathe out when releasing the tension.

Rhythmic breathing:

•Get into a comfortable position and relax all your muscles.

•Close your eyes or focus on a distant object if you prefer to keep them open.

•Breathe in and out slowly and comfortably through your nose. If you like, keep the rhythm steady by saying to yourself, "In, one, two. Out, one, two."

•Feel yourself relax and go limp each time you breathe out.

•You can continue this for just a few seconds or for up to 10 minutes.

Other forms of relaxation techniques that you can use include biofeedback, distraction, mental imagery, visualization and hypnosis.

About the Author: Bello Kamorudeen.For more information on Mesothelioma Chemotherapy go to http://www.mesotheliomacorner.blogspot.com


Source: www.isnare.com

Permanent Link: http://www.isnare.com/?aid=423872&ca=Cancer+Survival

Saturday, October 30, 2010

Influenza | Pleural Mesothelioma-symptoms, Diagnosis, And Treatment-basic

By: Bello kamorudeen

Pleural mesothelioma is the commonest type of mesothelioma. Mesothelioma is a rare form of cancer that attacks the mesothelial cells in the mesothelium, the tissue that forms the membranous lining of the body’s major internal organs and cavities.

Pleural mesothelioma develops when the cancer affects the pleura {the membranous lining of the lungs}.This form of cancer is commonest in the UK, followed by South Africa, then Australia, then USA, then Eastern Europe.

The pleura has two layers which gives support and protection to the lungs and chest cavity:

-The outer layer, or parietal layer, lines the entire chest cavity and the diaphragm.

-The inner layer or the visceral layer which applies directly over the lungs.

Pleural mesothelioma can start from any of these two layers then spread to the other layer. Exposure to asbestos has been strongly linked to the development of this type of cancer. The toxic fibers get trapped in the spaces between the mesothelial cells of the pleura.

Symptoms

The asbestos fibers trapped in the body cause cancerous cells to multiply and divide haphazardly without control. These results in the thickening of the pleural membrane and mesothelial cells, leading to fluid build up in the pleura {pleural effusion}. This accumulated fluid will gradually start pressing on the lungs and the respiratory system leading abnormal and difficult breathing.

These developments eventually form the basis of most of the symptoms of pleural mesothelioma. These symptoms include:

A} Persistent dry or raspy cough

B} Haemoptysis, the coughing up of blood in the sputum

C} Difficulty in swallowing {dysphagia}

D} Difficulty in breathing, labored breathing known as dyspnoea

E} Pleurisy, pain in the chest during breathing

F} Development of lumps under the skin of the chest wall

G} Night sweats or fever

H} Unexplained weight loss

I} Fatigue

Diagnosis

Just like in other forms of mesothelioma, the symptoms of pleural mesothelioma show up many years after the initial exposure to asbestos and these symptoms are not specific to pleural mesothelioma, they also occur in some other less serious lung diseases like pneumonia and influenza.

All these factors make the diagnosis of pleura mesothelioma very difficult.

Once there is a strong clinical suspicion of pleural mesothelioma, diagnosis is then confirmed by imaging tests such as x-rays, CT scan, to confirm the location of the cancer. The patient is also subjected to fluid and tissue analysis known as biopsy to confirm the type of cancer involved.

Treatment

Newly developed drugs and detection techniques have improved the outlook for patients with pleural mesothelioma.

In general there are three main modes of treatment: a} Surgery b} Chemotherapy c} Radiotherapy. Most patients receive a combination of two or more of the different modes of treatment.

The earlier the cancer is detected, the better the prognosis and the wider the range of treatment options. When the tumor is detected early, curative surgery is done to remove the cancer, this is followed by chemotherapy or and radiotherapy to kill off any remnant cancerous cells. Curative surgeries is only carried out in patients that have good general state of health and whose cancers have not spread beyond localized sections of the lungs.

The level of progression of the tumor is classified in terms of the stage of the cancer. The stages range from stage 1 to stage 4 depending on the level of spread of the tumor.

Stage 1 and Stage 2 pleural mesothelioma have better prognosis and better treatment options.

The latter stages of the cancer, namely stage 3 and stage 4 are mostly limited to palliative modes of treatment to improve the quality of life and not their prognosis. These palliative treatments include the draining of excessive fluids in the pleural spaces and surgical removal of tumors to relieve pressure on the lungs.

According to current studies, approximately 10% of all pleural mesothelioma patients will survive for three to five years after diagnosis and 5% will survive for 5 years and above.

Article Directory: http://www.articledashboard.com

Bello Kamorudeen.For more information on mesothelioma go to www.mesotheliomaconer.blogspot.com

Friday, October 29, 2010

Stage 4 Mesothelioma-Important Points For You To know

Author: Bello Gbenga

By the time mesothelioma has reached Stage 4 classification, the tumor has advanced and spread to different sites far away from the primary location. Most times mesothelioma spreads to vital organs like the brain, other areas in the chest cavity and into vital organs situated in the abdominal cavity.The TNM SystemThe TNM system categorizes cancer based on three factors:1} the size of the tumor, 2}whether the cancer has spread from its point of origin to nearby lymph nodes, and 3}whether the cancer has metastasized. This system may be used to stage pleural and peritoneal mesothelioma. The T stands for the size of the tumor, the N stands for the extent of lymph node involvement, and the M for the extent of distant metastases. This is the commonest staging system used for most cancers.The Butchart SystemThe Butchart System categorizes the different stages of the cancer based mainly on the size and spread of the primary tumor. This system has four stages. In Stage 4 of the Butchart system, mesothelioma has metastasized, spreading through the bloodstream to organs and tissues that are distant from the primary tumor site.The Brigham SystemThe Brigham system is a relatively new system of staging mesothelioma. This system classify mesothelioma into different stages based on whether or not tumors can be removed via surgery {resectability of the tumor mass}, and whether the cancer has spread to nearby lymph nodes. The Brigham system includes four stages. In Stage 4 of the Brigham system, mesothelioma is inoperable due to the large size of tumors and it has penetrated into vital organs. In addition, mesothelioma has metastasized to other locations, meaning cancer is more than likely to recur even if primary tumors are removed.How is Stage 4 Mesothelioma Treated?Patients with stage 4 have few treatment options. With Stage 4 mesothelioma, the prognosis is generally very poor due to the spread of cancer to multiple locations. Additionally, primary tumors have often penetrated too deeply into organs and tissues to be removed. The general health of stage 4 patients would have also declined to a level where the patient is too weak to withstand the physical stress of surgery.Stage 4 treatments are therefore limited to palliative treatments that are used to relieve symptoms of the disease. These may include procedures such as thoracentesis or paracentesis, where built-up fluid is removed from the lungs or abdomen to relieve pain and pressure on internal organs. Chemotherapy and radiotherapy may also be used to shrink tumors to provide symptomatic relief. As these treatments often have serious side effects, patients should carefully consider whether or not they wish to endure such treatments at this final stage.

Article Source: http://www.articlesbase.com/cancer-articles/stage-4-mesotheliomaimportant-points-for-you-to-know-1112292.html

About the AuthorBello kamorudeen.For more information on mesothelioma staging go to http://www.mesotheliomacorner.blogspot.com

Thursday, October 28, 2010

Mesothelioma Life Expectancy-What are your chances of survival?

Author: Bello Gbenga

About 2,000 to 3,000 new cases of mesothelioma is diagnosed every year in the United States of America. Mesothelioma is a rare form of cancer and it is an after effect of the asbestos exposure. The cancerous cells affect and destroy the mesothelium, which is a protective sac that holds the internal organs of the body. Initially, pleura or peritoneum are affected and then it spreads to the other parts of the body. It is a fatal disease and most victims do not survive beyond around one year after diagnosis, depending on the treatment and other contributing factors. What is mesothelioma prognosis? Prognosis for mesothelioma is dependent on the promptness of diagnosis and the treatment offered the victim. The earlier treatment is initiated the better the prognosis of the patient. Also other factors that determine prognosis include the type of treatment, the histological {cellular type} type of mesothelioma as well as patient’s general state of health and morale. The stage of the disease during diagnosis is another crucial factor that decides the prognosis and the minimum survival expectancy of the victim. Amongst the staging systems the oldest of them all is the Butchart system, based on the extent of mass, primary tumor and segregates the cancer into four stages. The TNM system is a more recent one while the Brigham system is the latest. It uses resectability and lymph node involvement for staging mesothelioma. Generally the higher the stage of the cancer the worse the prognosis of the victim. Sadly however most of the time diagnosis is made when the cancer is already in its advanced and latter stages, this is attributed to the long incubation period and the non specificity of the symptoms . The traditional kinds of treatments are also prevalent in case of malignant mesothelioma include Radiation therapy which uses high-energy X-rays to eradicate cancer cells and chemotherapy which tries to destroy the cancer cells with the use of anticancer drugs. Other forms of newer treatment options include Immunotherapy which helps to strengthen the immune system and photodynamic therapy that uses light energy while the genetic therapy resurrects the inherent genetic defects of the patient to fight the disease. Surgery is also one of the traditional modes of treatment. There are different types of surgeries that are used: the process of removing fluid from the chest is known as thoracentesis while fluid reduction from the abdomen is known as paracentesis. The surgical removal of a part of the chest or the abdominal lining is called pleurectomy and if the lung is removed, then the operation will be termed as pneumonectomy. When these treatment modalities are appropriately combined in the treatment of Mesothelioma especially in cases that are detected early, they can increase your 5 year life expectancy up to 10%.

Article Source: http://www.articlesbase.com/cancer-articles/mesothelioma-life-expectancywhat-are-your-chances-of-survival-929767.html

About the AuthorBello kamorudeen is the author of several mesothelioma articles.For complete information on mesothelioma visit http://www.mesotheliomacorner.blogspot.com

Malignant Peritoneal Mesothelioma- Important Facts for You to Know

Author: Bello Gbenga

Malignant peritoneal mesothelioma is rare form of cancer that affects the peritoneum, which is the lining of the abdomen. Every year, around 100-500 new cases are seen in the United States. It is also known as abdominal mesothelioma as the peritoneum protects and lines the abdominal cavity and the organs situated in the abdominal cavity. There are two layers of the peritoneal membrane called visceral and parietal layers. The visceral refers to the inner layer covering of the organs and the parietal refers to the outer layer covering of the abdominal cavity.The peritoneal membrane cells attacked by mesothelioma normally secrete lubricating fluids into the peritoneum, this allows for frictionless smooth movements of the organs in the abdominal cavity. However when these cells are transformed into cancerous abnormal cells, they start to over secrete this fluid leading to a gradual fluid build up in the abdomen.Abdominal Mesothelioma is usually secondary to a primary source of the malignancy, which is Pleural mesothelioma. It is believed that the asbestos fibers may be ingested when swallowed, where they enter digestive tract or that the fibers are inhaled into the lungs and transported via the lymphatic system to the abdominal cavity. Cancer cells from the primary source can also become mobile and spread via the lymphatic system to other areas, this process is called metastasis.Symptoms of peritoneal mesothelioma include:- Abdominal pain,- Swelling of the abdomen which may be caused by fluid retention (ascites)- Tumor growth into the intestine causing small or large bowel obstruction- Anemia-low blood level, which causes decreased oxygen levels in the blood, and makes the heart work harder, also causing shortness of breath- Weight loss, but you may appear larger around the waist- Fever.If you have been exposed to asbestos in your lifetime and you are having any of these symptoms, you should see your doctor immediately.Relatives of the mesothelioma victim are also at risk of developing the cancer. Spouses who handled dirty clothes to launder them are at risk to having asbestos transferred to them via physical contact with the fibers. Now that more is known about asbestos, workers must bathe and change clothes before going home. Special care is taken to limit exposure to the asbestos fibers.Diagnosis of peritoneal mesothelioma is similar to that of pleural mesothelioma. An x-ray will be taken. Mesothelioma cannot be seen on an x-ray, but a tumor may cause pleural effusion (fluid buildup) which can be seen. The doctor may also order a CT scan or an MRI to back up and add to the findings in the x-ray. Once the scans are done, a biopsy must be done to examine to tissue. The doctor will make a cut through the chest wall; this procedure is called a thorascopy. This will be done in the hospital under local anesthesia.The doctor may also perform a peritoneoscopy, which involves surgically inserting a scope into the abdomen to visualize the tumor cells and take tissue samples for biopsy. The procedure is similar for both thoracic and abdominal examinations. Samples of tissue obtained will be examined by the pathologist under the microscope.Mesothelioma is quite rare, so if you are diagnosed with it, you should have your doctor help you find a specialist who is well versed and experienced in the treatment of the disease and there are not too many of such specialists. There is no cure for malignant mesothelioma, but there are treatment options that include surgery, radiation, chemotherapy, and others. The life expectancy of someone with malignant peritoneal mesothelioma varies from person to person. The prognosis depends on how vigorously the cancer is treated and how the patient responds. The patient may live for years, or only for a few months.

Article Source: http://www.articlesbase.com/cancer-articles/malignant-peritoneal-mesothelioma-important-facts-for-you-to-know-1112267.html

About the AuthorBello kamorudeen.For complete information about mesothelioma go to http://www.mesotheliomacorner.blogspot.com

Wednesday, October 27, 2010

Peritoneal /Abdominal Mesothelioma Information-Basic facts you need to know

Author: Bello Gbenga

Peritoneal Mesothelioma is a type of cancer that affects the peritoneum, which is the protective lining of the abdomen. Hence, this disease is also known abdominal mesothelioma. The peritoneum has two layers, the visceral and the parietal peritoneum. The visceral peritoneum is the inner layer that envelops the abdominal organs and forms the periphery of the intestinal tract. On the other hand, parietal peritoneum is the outer layer that covers the abdominal cavity. The purpose of these layers is to protect the internal organs and to secrete a lubricating fluid that eases the movement of internal organs in the abdominal cavity.Causes of Peritoneal MesotheliomaIt is widely believed that asbestos is the main cause for peritoneal mesothelioma. According to medical opinion, there are two ways asbestos dust could reach the intestine lining, one through involuntary ingestion during working long hours and days amid asbestos, and secondly, through the lungs while breathing and via the lymph nodes to the peritoneal cavity. Either way, it is harmful to the human body, and may invariably lead to this cancerous condition if exposed to for a longer period of time.Symptoms of Peritoneal MesotheliomaPeritoneal mesothelioma, like the other forms of mesothelioma, shows a very long latency period and its symptoms show up 20 -30 years after asbestos exposure. Most often by this time it will be too late to effectively treat the disease or provide any constructive medication or treatment. Also because most of the symptoms are not specific to the cancer, a diagnosis of the cancer is usually not made quickly. For example, the common mesothelioma symptoms include anemia, fever, weight loss, abdominal pain, and bowel obstruction, and it is highly likely that the doctor initially may consider other options than contemplating cancer. Therefore, the patient telling the doctor about any previous asbestos exposure during the first consultation visit is very crucial, and that helps the doctor to think of a possible mesothelioma threat even before considering other possibilities.TreatmentsOnce the disease has been diagnosed, the doctor recommends the treatments based on several factors such as the extent of the spread of the cancer, age and medical history of the person and the general state of health of the person. The traditional treatments for mesothelioma include surgery ,radiation therapy- external and internal radiation, and chemotherapy, which involves the use of anti cancer drugs that are given either orally or intravenously.With the advancement in science and technology, newer treatment techniques have been introduced, and some of them look promising.Intraoperative photodynamic therapy is one such newer method that uses special drugs and light to destroy cancer cells. Immunotherapy which is a way of boosting the immunity of ones own body against the spread of cancer is another new form of therapy. Also, recently, researches have found that Gene Therapy is effective in correcting the faulty genes causing mesothelioma. These two methods are however still in the clinical trials and are yet to be implemented in the general population. Even though a wide range of treatments are available for mesothelioma, clinical experiences reveals that none of this alone is capable of treating the disease effectively. Therefore, it is a selected combination of some of these treatments called the "multimodality approach" that is commonly followed and the different modes of treatments to be used are decided by the doctor based on the general state of health of the patient , the level of advancement of cancer and his/her age.

Article Source: http://www.articlesbase.com/cancer-articles/toneal-abdominal-mesothelioma-informationbasic-facts-you-need-to-know-1112615.html

About the AuthorBello kamorudeen is the author of several mesothelioma articles.For more information on mesothelioma types ,symptoms and treatment visit http://www.mesotheliomacorner.blogspot.com

Tuesday, October 26, 2010

Mesothelioma Treatment Centers-How do they help?

Author: Bello Gbenga

As Mesothelioma is a relatively uncommon disease, there are very few dedicated treatment centers in the US and in other places of the world. This limits the choice of mesothelioma victims in finding centers for specialized and specific help for their condition.Most major hospitals however have highly specialized general oncology{cancer} departments where mesothelioma victims can get the necessary treatment for their disease.Cancer treatment centers elicit different emotions in many people. The presence of so many critically ill people searching desperately for a cure can cause fear and depression, while others draw inspiration from the devotion of so many professionals working for a common cause or the courage of terminally ill people fighting their terrible conditions. In reality, these impressions vary greatly from individual to individual depending on their previous experiencesClearly, the disposition of the person suffering from this deadly disease will greatly affect the opinion they draw from these centers.Cancer centers usually provide a number of different services. They provide specialized treatment and management for the different types of mesothelioma cancer, they also provide spiritual, emotional, and legal counseling for the patients and their families. Cancer is responsible for a variety of ancillary conditions, and many of the patients need help coping with the side effects of treatment, or require advice on how to plan their estates.Treating cancer in a medical center often provides the best hope for victims of mesothelioma, but the expense of travel, lodging, and treatment often prohibit many victims from pursuing adequate treatment. To this end, consulting a lawyer about potential action against the negligent parties responsible for your condition can provide the means to seek such treatment. Victims of mesothelioma know time is of the essence, but more so when you consider your state has limits on the amount of time you have to press your claim. Don't risk losing more than you already have. Contact an attorney without delay.List of some of these centers are:ALABAMA Birmingham University of Alabama at Birmingham Comprehensive Cancer Center 1824 Sixth Avenue South Birmingham, AL 35294-3300ALASKA Fairbanks Memorial Hospital, Fairbanks, AKCALIFORNIA Los Angeles Tower Hematology/Oncology 8635 West Third Street, Suite 665W Los Angeles, CA 90048San Diego Sharp Health Care 10835 Road to the Cure San Diego, CA 92121COLORADO Denver University of Colorado 4200 East 9th Avenue, B-189 Denver, CO 80262FLORIDA Miami Oncology Hematology Group of South Florida 8940 North Kendall Drive, Suite 300E Miami, FL 33176ILLNOIS Chicago University of Chicago Medical Center, Section of Hematology/Oncology 5841 S. Maryland Avenue, MC2115 Chicago, IL 60637-1470

Article Source: http://www.articlesbase.com/cancer-articles/mesothelioma-treatment-centershow-do-they-help-1112212.html

About the AuthorBello kamorudeen.For more information on Mesothelioma and Mesothelioma treatment visit http://www.mesotheliomacorner.blogspot.com

Monday, October 25, 2010

How to Choose the Best Home Care Service For Mesothelioma Patients

Author: Bello Gbenga

Much of the care that you are going to get as a mesothelioma cancer patient will be given in an outpatient setting, which includes home care. In many ways, home care for the person with cancer is no different than the home care that is given to people with other kinds of illness.

A mesothelioma patient will need help with diet and nutrition, physical therapy, home health aides, speech and respiratory therapy, personal care, emotional support, volunteer services, pharmacy, support from clergy, and other kinds of care.

Also skilled nursing services involving the use of an oncology nurse specialist, who is an expert in cancer care might be available for home care treatment of the mesothelioma patient. Many of these same services are also offered as part of hospice care.

Some of the home care services that could be provided for the mesothelioma patient are:

- chemotherapy

- immunotherapy or biologic therapy (which use different parts of the body's immune system to fight cancer or lessen the side effects of some cancer treatments)

- blood products

- pain management

- antibiotic treatment

- nutritional support

- anti-emetic therapy (treatment for vomiting)

- hydration (giving of fluids, usually IV or through a feeding tube, for patients who cannot drink enough liquids). These infusion therapies can be given at home by home care agencies.

There are some points that you must consider if you want ton choose the best home agency for your care. You must first of all discuss with your health team to know the types of services you will need. Then you can find agencies that offer those services.

Find out about the accreditation, licensing, and certification of the agencies that you are considering. Also ask questions about your prospective agencies quality of cancer care, the type of experience they have with providing cancer care services, and the skills and training of staff at the agencies you are considering.

There are a number of questions you might ask when you're looking at a home care service:

Certification

Are the home care providers that you are considering Medicare-certified? Medicare-certified programs have met federal requirements for patient care and management. Home care providers are closely supervised and controlled. Medicare certifies only agencies with skilled nursing care. To find a Medicare-approved home health agency, you can visit "Home Health Compare" on the Web at www.medicare.gov. This helpful tool is listed under the search tool "Compare Home Health Agencies in Your Area" on their home page. It gives you names, addresses, and phone numbers of nearby agencies. You can also look at quality measures and compare how well the home care agencies deal with common health problems.

Accreditation

Is the agency you are considering accredited by a nationally recognized accrediting body, such as the Joint Commission? You can look up the agency on the Joint Commission Web site at www.qualitycheck.org. The Joint Commission is an independent, not-for-profit organization that evaluates and accredits health care organizations and programs that volunteer for their review. Accreditation is an important measure in selecting quality health care services. You can ask to see the results of the home care agency's most recent Joint Commission survey.

References

How many years has the agency been serving your community? Can the agency give you references from cancer care professionals, such as an oncologist, oncology nurse, cancer center, or an oncology social worker, who have used this agency? Ask for names and phone numbers. A good agency will give these to you if you ask. Talk to these people about their experiences. You may also wish to check with your local Better Business Bureau, your local Consumer Bureau, or the State Attorney General's office. They can tell you if complaints have been filed against the agency.

Licensure

Is your prospective care provider licensed by your state?Most states require licensing of home health agencies.

Consumer information

Does the agency have written statements that list services (including cancer care services), eligibility requirements, costs and payment procedures, staff job descriptions, and malpractice and liability insurance? Ask that they send you any brochures or other information they can share about their services.

Article Source: http://www.articlesbase.com/cancer-articles/how-to-choose-the-best-home-care-service-for-mesothelioma-patients-1292437.html

About the AuthorBello kamorudeen.For more information on mesothelioma home care providers go to http://www.mesotheliomacorner.blogspot.com

Sunday, October 24, 2010

How to Cope With a Terminal Mesothelioma Relative

Author: Bello Gbenga

Mesothelioma cancer is often a terminal illness with most victims dying within one year of diagnosis. This grim fact is a very difficult fact that victim and the people around them will have to face. The person with cancer may be in pain, may be incapacitated by the cancer or may be able to walk only a few steps, or may be confused. It is hard to watch someone you love gradually pass away in this manner.

No matter how hard it may be, it is still important to try to be there for the person. The person with cancer may feel lonely even if there are people around. This is because the people nearby may not be really in tune with what is going on with the person. You can be the person who is in sync with your loved one every step of the way. Just by staying close and listening with a smile or gentle touch, you show you are there for your friend or family member. It takes courage and extra energy to be in this situation.

Sometimes the person with advanced mesothelioma cancer may pull away from people and seem to be withdrawing as he enters the dying process. This is usually a natural process and is one way of disconnecting from life. The best thing you can do if this happens is to take the person's cue, and simply stay in the background and be available. Try not to take this withdrawal personally or feel hurt when the person pulls away. It likely has nothing to do with you.

Most people do not what to say when a person talks about dying. This is a very common occurrence. Some people want talk about different parts of the dying process, they want to know what to expect. Some want to know how they will die, and ask, "What will happen when I'm actually dying?" For answers to these questions, you will need to find experts in hospice care or care of the terminally ill. If you don't know the answers to specific questions, you can say, "I don't know, but we will call some people who can help us with those answers." These professionals can guide you and the person with cancer by explaining the things that might happen as death gets closer.

Hospice staff members are used to answering these questions, and they are skilled in answering doing it in a supportive, caring way. In many communities, hospice organizations give expert, compassionate care for people with advanced disease.

The mesothelioma victim might ask you why the cancer is afflicting him or her. This is a very tough question to answer because there is really no answer, and it is heart wrenching to feel the pain that lies within such a question. It is always better to give the simple answer "I don't know" and hold the hand of the victim and let the person cry or talk about their sadness and regrets. Allowing a person to do this is a true help because so many people avoid the topic of dying and won't allow themselves to feel this pain with their loved one.

Sometimes dying mesothelioma victims may feel the need to get some things off their chests. They may want open up to you about some of the things they did in their life that they are not proud of and they are now regretting. They may want to apologize about these things. They may want to give you instructions about what to do for them in the future.

Respectfully listening and, of course, providing forgiveness and a loving attitude are all that's needed. There are no magic words for the dying person, but often your presence is like magic and having an open heart is priceless.

Article Source: http://www.articlesbase.com/cancer-articles/how-to-cope-with-a-terminal-mesothelioma-relative-1347019.html

About the AuthorBello kamorudeen.For more information on Mesothelioma visit http://www.mesotheliomacorner.blogspot.com

Saturday, October 23, 2010

Terminal Mesothelioma Cancer-How to Recognise a Dying Mesothelioma Victim

Author: Bello Gbenga

When the mesothelioma victim begins to show signs of imminent death, it is the time to for the relatives and friends to come around to say final goodbyes to their loved one. One after the other, the family members and friends might spend time with the patient, holding hands, talking to the patient, or just sitting quietly by the patient.

It can also be a time to perform any religious rituals and other activities the patient desires before he/she passes on. It is a chance for many families and friends to express their love and appreciation for the patient and for each other.

This also the time to plan for what to do after the death of the patient, so that the family will not be confused about what to during this very emotional time. If the patient is in hospice, the hospice nurse and social worker will help you. If the patient is not in hospice, talk with your doctor about it so that you will know what to do at the time of death.

These are some of the symptoms that will be seen in a dying mesothelioma cancer patient:

1- Changes in body function

•profound weakness,usually the patient cannot get out of bed and has trouble moving around in bed

•needs help with nearly everything he or she does. May be unable to change positions without help

•less and less interest in food, often with very little food and fluid intake for days

•trouble swallowing pills and medicines

•more drowsiness--the patient may doze or sleep much of the time if pain is relieved. May be restless and pick or pull at bed linens. May be hard to rouse or wake. Anxiety, fear, restlessness, and loneliness may worsen at night

•cannot concentrate, has short attention span

•confused about time, place, or people

•limited ability to cooperate with caregivers

•involuntary movement of any muscle, jerking of hands, arms, legs, or face

2- Changes in consciousness

•more sleeping during the day

•hard to wake or rouse from sleep

•confusion about time, place, or people

•restless, may pick or pull at bed linen

•may talk about things unrelated to the events or people present

•may have more anxiety, restlessness, fear, and loneliness at night

•after a period of sleepiness and confusion, may have a short time when he or she is mentally clear before going back into semi-consciousness

3- Changes in metabolism

•less interest in food -- the patient has less need for food and drink

•mouth may dry out (see the next section on changes in secretions)

•may no longer need some of his or her medicines, such as vitamins, replacement hormones, blood pressure medicines, and diuretics (unless they help make the patient more comfortable)

4- Changes in secretions

•mucus in the mouth may collect in the back of the throat (This may be a very distressing sound to hear, but doesn't usually cause discomfort to the patient.)

•secretions may thicken due to less fluid intake and build up because the patient cannot cough

.
5- Changes in circulation and temperature

•• arms and legs may feel cool to the touch as circulation slows down

•skin on arms, legs, hands, and feet may darken in color and look mottled (blotchy dark spots)

•other areas of the body may become either darker or paler

•skin may feel cold and either dry or damp

•heart rate may become fast, faint, or irregular

•blood pressure may get lower and become hard to hear

6-Changes in senses and perception

•vision may become blurry or dim

•hearing may decrease, but most patients are able to hear you even after they can no longer speak

7- Changes in breathing

•breathing may speed up and slow down due to less blood circulation and build up of waste products in the body

•mucus in the back of the throat may cause rattling or gurgling with each breath

•the patient may not breathe for periods of up 10 to 30 seconds

8- Changes in excretion

•urine may become darker and decrease in amount

•when death is near, the patient may lose control of urine and stool

Signs of irreversible death also known as "brain death"

-Cessation of breathing as the patients chest becomes still, not showing normal respiratory movements.

-Blood pressure becomes unrecordable

-Nil pulse in the blood vessels as the pulse stops

-Still immovable eyes with fixed wide gaze

-Open fixed pupils of the eyes, even in bright light

-Loss of control of bowels or bladder function as the muscles relax

After death it is all right if you sit with your loved one for a while. There is no rush to get anything done right away. Many families find this is an important time to pray or talk together and reconfirm their love for each other, as well as for the person who has passed away.

If the patient dies at home, caregivers are responsible for calling the appropriate people. Regulations or laws about who must be notified and how the body should be moved differ from one community to another. Your doctor or nurse can get this information for you. If you have a hospice or home care agency involved, call them. If you have completed funeral arrangements, calling the funeral director and doctor are usually all that you have to do.

Article Source: http://www.articlesbase.com/cancer-articles/terminal-mesothelioma-cancerhow-to-recognise-a-dying-mesothelioma-victim-1347038.html

About the AuthorBello kamorudeen.For more information on Mesothelioma go to http://www.mesotheliomacorner.blogspot.com

Friday, October 22, 2010

Vitamin a - Possible New Drug For Mesothelioma

Author: Bello Gbenga

Vitamin A is a very important vitamin to maintaining health. Vitamin A is found in foods like carrots and it is well known for its importance in maintaining eyesight. Also recent independent research studies over the last three decades have suggested that vitamin A could possibly have an impact on managing and preventing mesothelioma.

Vitamin A has many essential functions in the human body including:

- sustenance of vision

- bone growth

- Reproduction

- Cell division

- Cell differentiation

- Helping to maintain the immune system - the body's defense against infection.

Vitamin A comes from animal sources (such as liver and whole milk) and plant sources.
Retinoids which are chemically related to vitamin A have been implicated as anti-carcinogenic. For example, according to an article published in a leading medical journal: "At the cellular level, the anti-leukemia and anti-cancer activity of retinoids is the result of three main actions, cell-differentiation, growth inhibition and apoptosis."

In a 1988 study performed by the National Cancer Institute, the dietary patterns of mesothelioma patients were compared to those of healthy individuals. According to the article, mesothelioma patients ate less homegrown, cruciferous vegetables and all vegetables combined before they were diagnosed compared to healthy patients. Cruciferous vegetables, also called Brassica Vegetables, include Arugula, Broccoli, Cauliflower, Brussels Sprouts, Cabbage, Watercress, Bok Choy, Turnip Greens, Kale, and Mustard Greens. The researchers also pointed out that carotene intake was significantly lower for the mesothelioma patients. Carotene is a precursor to vitamin A.

In this 1996 study from the Division of Epidemiology of the American Health Foundation, the investigators examined the association between dietary intake and mesothelioma by studying 94 men and women with malignant mesothelioma and 64 people without cancer. They concluded that their results provided "some justification for the hypothesis that provitamin A or beta-carotene may decrease the risk of mesothelioma. Provitamin A is any of the carotenoids that are precursors of vitamin A and can be found in fish-liver oils, egg yolk, milk products, green-leaf or yellow vegetables, and fruits.

In a study from 2002, researchers looked at mesothelioma cells in vitro (in test tubes or Petri dishes outside the body) and found that retinoic acid (the oxidized form of Vitamin A) "may lead to a decrease of mesothelioma cell local invasion." They interpreted this to mean that retinoic acid may modify how mesothelioma grows and spreads in the body. This study suggests that vitamin A levels could possibly affect the aggressiveness of mesothelioma once someone is diagnosed with the disease, thus making mesothelioma metastases unlikely.

And in 2006, Australian researchers looked at former workers and residents exposed to crocidolite (blue asbestos) in Western Australia. Their findings suggested that "people with chronically low plasma levels of retinol (the fat-soluble animal form of vitamin A found in liver and eggs) have increased risk of developing mesothelioma and lung cancer."

Will vitamin A eventually become part of conventional treatment modality for the prevention or treatment of mesothelioma? These independent studies are very preliminary, but their conclusions are intriguing. In addition, there are anecdotal reports of long-time mesothelioma survivors using vitamin A as part of their healing regiments. But first a great deal more research is needed.

Mesothelioma patients willing to add Vitamin A as part of their cancer treatment should discuss with their doctor on the use of Vitamin A before proceeding on the use.

Article Source: http://www.articlesbase.com/cancer-articles/vitamin-a-possible-new-drug-for-mesothelioma-1346995.html

About the AuthorBello kamorudeen. For more information on mesothelioma visit http://www.mesotheliomacorner.blogspot.com

Thursday, October 21, 2010

Mesothelioma Chemotherapy-What is the Role of Alimta?

Author: Bello Gbenga

Mesothelioma is a notoriously difficult asbestos related cancer to treat. Most chemotherapy drugs that have been used to treat this type of asbestos cancer have not had appreciable success in the treatment of this deadly cancer.

Among recently approved medications, Alimta stands out as having the most promise in prolonging the life of mesothelioma patients, as well as improving their quality of life.

Alimta, also known as Pemetrexed is a newer chemotherapy medication that was approved by the Food and Drug Administration (FDA) in 2005. Most times it used in combination with Cisplatin ,and Alimta is the first medication that is specifically approved for the treatment of mesothelioma and is considered to be the most effective chemotherapy treatment for pleural mesothelioma patients especially those that have advanced cancer that are not candidates for surgery.

Alimta is a multi-targeted anti-folate medication that works by blocking the enzymes required for DNA replication and cell division. During clinical trials, Alimta (used in tandem with Cisplatin) added an average of three months to the lives of malignant mesothelioma patients and also helped to reduce symptoms.

As with most cancer medications, it is imperative for patients to discuss the use of Alimta and Cisplatin with their doctor before beginning cancer treatment. An oncologist will provide facts about the effectiveness of Alimta, the administration of the medication, and the side effects patients encounter.

Cancer specialists doctors usually recommend the complimentary use of B12 supplements given intramuscularly{injection}and folic acid supplements given orally on a daily dosage (supplementation will continue for 21 days after the last dosage cycle of Alimta).

Patients are also placed on adjuvant oral steroids to help minimize side effects. Patients should inform their doctor of all other medications being taken to avoid dangerous interactions.

Alimta is given to mesothelioma patients every 21 days on an outpatient basis. Treatment consists of a 10-minute IV infusion, followed by two hours of Cisplatin. The number of cycles patients are required to receive will depend on their response to the medications and intensity of resulting side effects.

Side Effects

The side effects of Alimta are usually mild to moderate for most patients with pleural mesothelioma. Some patients may experience extreme side effects and a doctor should be informed immediately if a reaction becomes a serious problem. Side effects typically include:

•Nausea

•Vomiting

•Fatigue

•Constipation

•Diarrhea

•Loss of appetite

•Weight loss

•Tiredness
•Weakness
•Pale skin
•Headache
•Dizziness
•Confusion
•Fast heartbeat
•Difficulty falling asleep or staying asleep
•Changes in mood
•Depression
•Joint or muscle pain
•Low red blood cells count(anemia)
•Low white blood cells count(neutropenia)
•Low platelets count(thrombocytopenia)


Patients experiencing any of the following symptoms should immediately call their doctor:

•Diarrhea
•Sores in the mouth, throat, or on the lips
•Unusual bleeding or bruising
•Sore throat, fever, chills, cough, or other signs of infection
•Chest pain
•Difficulty breathing or swallowing
•Slow or difficult speech
•Weakness or numbness of an arm or leg
•Pain, burning, numbness, or tingling in the hands or feet
•Hives
•Rash
•Itching
•Decreased urination

Mesothelioma patients should avoid being near people who have colds, the flu, or other signs of illness because during chemotherapy the immune system is weakened by the chemo drugs thus making the patient very prone to "catching" infections.

Make sure to contact your doctor at once if you develop signs of an infection. Before you receive Alimta, tell your doctor if you are taking an NASAID, such as ibuprofen, naproxen, indometacin, ketoprofen, and others, these drugs tend to interact negatively with Alimta. Also before receiving Alimta, tell your doctor if you have kidney disease,liver disease,immune deficiency or the presence of excessive fluid in your lungs or in any organ in your body.

Article Source: http://www.articlesbase.com/cancer-articles/mesothelioma-chemotherapywhat-is-the-role-of-alimta-1317353.html


About the Author

Bello kamorudeen.For more information on mesothelioma treatment go to http://www.mesotheliomacorner.blogspot.com

Wednesday, October 20, 2010

Mesothelioma Chemotherapy - Do You Know the Schedule of Treatment and Common Side Effects?

Chemotherapy Schedules

How often you will receive chemotherapy will be determined by your doctor, taking into consideration factors such as the stage of your cancer, the types of drugs you receive, the anticipated toxicities of the drugs and the time necessary for your body to recover from these toxicities. The doctor may also consider whether the goal of the chemotherapy is to control the growth of the cancer, or to ease symptoms associated with the disease.

In general, chemotherapy treatment is administered in "cycles" - a "cycle" being defined as a period of treatment followed by a period of rest. This cycle allows the cancer cells to be attacked by the drugs, and then allows the body's normal cells time to recover. The combination of drugs used, the length of time to administer the drugs, how often they should be repeated and the number of cycles recommended have been analyzed very well in clinical trials.


For mesothelioma patients, the "standard" treatment is a combination of Alimta and cisplatin, administered IV, with a 10 minute infusion of Alimta followed by two hours of cisplatin, given in 21 day cycles. Modifications to this schedule may be made according to what your doctor feels is appropriate in your particular case.

The number of treatment cycles, or the length of time between the beginning and end of chemotherapy may vary, however in general, 3 to 4 cycles of treatment are given before response is evaluated; 2 to 3 cycles are considered a minimum to assess for effectiveness. After response to the treatment has been determined, the following criteria will be used to decide whether chemotherapy should continue:

• If there is shrinkage of the tumor, or the disease is kept stable, chemotherapy may be continued for as long as it can be tolerated and there is no disease progression.


• If there is continued disease progression, chemotherapy will be stopped, and the patient will be given alternative options.
The goal of setting a chemotherapy schedule is to make treatment as effective, timely and trouble-free as possible, but while the drugs are working to kill cancer cells, they may also affect healthy cells causing side effects.

Common Side Effects of Chemotherapy Includes:
-Fever of, or greater than 101 degrees
-Nausea
-Diarrhea or constipation
-Fatigue
-Tingling or numbness in the fingers or toes
-Ringing in the ears
-Bruises or rashes
-Sores in the mouth or throat
-Reduced white blood cell count {neutropenia} making you more prone to infections. For this reason your full blood count should be monitored closely.

Be sure you report all over-the-counter and prescribed medicines to your physician. Don't take aspirin unless it has been approved by your physician. Ask your pharmacist if aspirin is part of the drugs you want to purchase.

Stay away from people who have colds or the flu. Chemotherapy can compromise your immune system and lower your resistance to germs.

It is normal to feel sad, angry or afraid, however, letting these emotions get out of control can affect negatively your overall well-being. Look out for the help of family, friends, your doctor, a counselor or a support group.

Chemotherapy treatment should be a cooperative effort between you and your doctor. The interaction that takes place is important to your health. It will not only help you feel better, but will also address any potential problems with improper communication.

Patients should educate themselves about mesothelioma and treatment options and reach out to available resources to make coping with a mesothelioma diagnosis easier.

Bello kamorudeen is the author of several mesothelioma articles. For complete information on mesothelioma and its treatments visit http://www.mesotheliomacorner.blogspot.com

Bello Gbenga is a General Medical Practioner and independent health researcher. He was also a former hemorrhoid sufferer and has been practicing medicine for the past ten years during which he has attended to several hemorrhoid victims. He reviews health related products and he writes articles for several online health stores and health related websites.

Monday, October 18, 2010

Mesothelioma Prognosis Why Do Some Patients Survive Longer?

By: Bello Kamorudeen

There have been some few patients who have survived far beyond the usual one year prognosis for most mesothelioma victims and a handful that have even been cured, with no trace of the aggressive cancer several years after treatment (though recurrence is always possible).

Many medical experts are baffled by this observation and for most of the time they are yet to find a real scientific basis to explain why some mesothelioma patients survive and others do not.

There seems to be one common factor amongst those that have survived the disease for longer times the immune system. Studies of those who have either survived or been cured of the disease reveal that most of these patients participated in some sort of therapy that enhanced their immune system. Some treatments included clinical trials in immunology while others involved alternative therapies dealing with the immune system.

A number of mesothelioma survivors have posted their stories on the Internet and have spoken to patients and their families with the hope of providing a brighter outlook for their future. These same survivors have also presented their cases to doctors and researchers. The most outspoken of these individuals is Paul Kraus, an Australian mesothelioma survivor. Kraus was diagnosed with abdominal/ peritoneal mesothelioma in 1997, a form of the disease that is tougher to treat than the more common pleural mesothelioma. Kraus worked in a factory 35 years earlier where he was exposed him to blue (crocidolite) asbestos.

Upon his diagnosis, Kraus changed his diet (he s now a vegetarian), added many vitamins and supplements to his daily routine, began juicing, and tried a treatment known as ozone therapy. Kraus explains, They took blood out of a vein, used an ozone machine to add ozone (a molecule composed of three oxygen atoms) to the blood and reintroduced it into my body through a drip. The rationale for that was that cancer does not like an oxygenated environment. The research in putting the protocol together took a lot of time, but in the long run, Kraus believes the combination of all these treatments stabilized his mesothelioma. Today, tests show he still has the disease and his body is a bit weaker than it was, but he has no pain and his doctors tell him he has many more years to live. Kraus stresses the fact that he is not the only mesothelioma survivor.

He has cited the case of a man diagnosed 14 years ago at age 58 (no name given) who had a chest wall resection after diagnosis and has had no symptoms or recurrence since. His doctors believe there was moderate host inflammatory response and that spontaneous regression may be an immune mediated phenomenon in other words, his immune system played a role in his survival.

Another survivor, Rhio O Connor who recently published a book about his fight with mesothelioma has lived with the disease for seven years. He opted against the conventional methods of treatment like surgery, chemotherapy and radiotherapy. Instead, with the help of several medical physicians, he developed a regimen that included 100 supplements per day, changed his diet drastically, and now practices what he calls mind body medicine (such as non stress techniques like meditation). In his book, he recommends a variety of alternatives to traditional medicines and treatments.

All mesothelioma patients should be encouraged to participate in clinical trials especially those that are trying out new methods of boosting the immune system.


Author Resource:-> Bello Kamorudeen.For more information on mesothelioma treatments and clinical trials go to http://www.mesotheliomacorner.blogspot.com

Saturday, October 16, 2010

Mesothelioma Blood Test Mesomark Test

By : Bello Kamorudeen

The reason for high death rates among mesothelioma patients is the aggressive nature of the disease and the inability to diagnose it until it is well advanced. Because mesothelioma symptoms do not show up until about 40 50 years after exposure to asbestos, most cases at the time of diagnosis have already reached Stage III or IV. As a result, mesothelioma treatment options are often more palliative than curative.

However, the ability to diagnose the disease at an earlier time would certainly result in a better prognosis for mesothelioma patients. That ability is now present in the form of a mesothelioma blood test known as Mesomark. Developed by Fujirebio Diagnostics Inc. of Malvern, Pennsylvania, a leader in the field of oncology testing, the test measures the amount of a particular biomarker in human serum.

The test was first released in Australia in March 2005 and distribution expanded to Europe just a few months later. Food and Drug Administration approval for the blood test was received nearly two years later in January 2007.

Testing for Mesothelioma

Mesomark is an easily performed blood test that uses an enzyme linked immunosorbent assay to measure the amount of Soluble Mesothelin Related Peptides (SMRP) in human serum. SMRP is a biomarker that is produced by mesothelioma cells, and this biomarker may be elevated in the serum of patients who have mesothelioma. The detection of the biomarker through a blood test can help attain an early diagnosis, resulting in more treatment options and a better prognosis for patients.

Mesomark is what is referred to as an in vitro test. In this test, the blood that is drawn from the patient is sent to a laboratory to measure the level of SMRP. This is performed by using monoclonal antibodies that are known to specifically bind to SMRP. Measuring the amount of bound antibodies in the blood indicates the amount of SMRP, and certain levels indicate the presence of mesothelioma. In addition to detecting the presence of mesothelioma in yet to be diagnosed patients, the Mesomark blood test may also be used to monitor the success of treatments in patients who have already been diagnosed with the disease.

These tests will also help determine the next course of treatment.

The Mesomark blood test has NOT yet been approved for the early diagnosis of mesothelioma.

This test has been approved as a Humanitarian Use Device (HUD), meaning that physicians must follow certain procedures to qualify their patients for testing. Once the physician is certified, informational brochures will be sent to be distributed to each applicable patient.

Those wishing to take part in Mesomark testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.

The costs associated with the Mesomark blood test may not be covered under health insurance, therefore, you may be required to pay all or part of the costs out of pocket. It is recommended that you check with your insurance carrier to determine whether coverage is available under your policy.

Author: Bello kamorudeen.For complete information on mesothelioma diagnosis visit http://www.mesotheliomacorner.blogspot.com

Immunotherapy -A New Way of Fighting Mesotheloma

Conventional cancer treatments like radiotherapy and chemotherapy are more widely used to treat mesothelioma, but alternative treatments such as immunotherapy are becoming more and popular too. Other therapies such as immunotherapy provide the patient with additional options for the control of symptoms. While immunology does not yet offer a cure for mesothelioma, researchers continue to experiment with the treatment in hopes of achieving better results.

Immunotherapy involves the use and manipulation of a patient's own immune system to help them fight diseases to which the immune system would not normally respond.

In the case of mesothelioma and other types of asbestos cancer, the patient's immune response does not typically react or destroy cancer cells for one very important reason: a normal healthy immune system does not recognize cancer cells as foreign cells so it does not destroy them.

Immunotherapy is a type of treatment that tricks the immune system into believing that cancer cells are foreign. When this type of treatment is administered to cancer patients, the immune system can be made to destroy cancer cells, while leaving normal healthy cells unharmed.

Treating mesothelioma patients with immunotherapy relies on helping the body's immune system to recognize the difference between healthy cells and cells that have become cancerous.

To understand how immunotherapy works, it is first important to understand how the immune system differentiates between normal body cells and foreign cells. The immune system does this by recognizing and reacting to antigens. Antigens are molecules that are present on the surface of all cells, whether human, bacterial, or viral. A normal immune system can react to and destroy cells that produce antigens that are foreign, but cannot react to cells that produce "self" antigen (an antigen produced by the body).

Immunotherapy, therefore, is geared towards making the immune system recognize antigens on cancer cells as being foreign, allowing the immune system to destroy those cells. There two ways by which immunotherapy can be used:1]Active immunity and 2]Passive immunity

Active Immunotherapy for Mesothelioma

Active immunotherapy treatments stimulate the immune system to fight disease. Vaccines, for example, are a type of active immunotherapy. Cancer vaccines are slightly different in that they are designed to fight diseases that already exist in the body, whereas most other vaccines are administered to prevent disease.

Mesothelioma vaccines may be created by removing cancer cells from a mesothelioma patient. This is usually done in a laboratory by using either whole cancer cells or antigens removed from cells. The cells or antigens are modified in a laboratory so they can be recognized by the patient's immune system and are then injected back into the patient.

Active immunotherapy treatments for mesothelioma are highly specific treatments made with cells from the patient's own body. Thus, a different vaccine is created for each patient who receives active immunotherapy treatment.

Passive Immunotherapy Treatment for Mesothelioma

Passive immunotherapy treatments are those which use components that are created outside the body. These types of treatments differ from active immunotherapy in that passive treatments do not attempt to force the immune system to actively destroy cancer cells.

One example of a passive immunotherapy treatment is monoclonal antibody therapy, which is currently the most widely used immunotherapy for treating cancer. Antibodies are molecules the immune system produces to help fight infections. In an immune system that is functioning normally, antibodies are produced that recognize and bind to foreign antigens present on foreign cells, which effectively targets foreign cells for destruction by other parts of the immune system.

Monoclonal antibody therapy involves removing cancer cells from a patient, which are then grown together in a laboratory with other cells that produce antibodies in response to antigens on the cancer cells. During this process, identical antibodies are produced that recognize the same antigen (hence the termed monoclonal).

The next stage of the treatment involves injecting the patient with the monoclonal antibodies. Once inside the body, the antibodies recognize and bind to tumor cells, as the tumor cells possess the specific kind of antigen that the antibodies were created to identify. If the cancer treatment is successful, the immune system will recognize the monoclonal antibodies and destroy the cancer cells.

Immunotherapy is however still largely in experimental stages of different clinical trials all over the world and most of them are yet to be approved for general use, so if any mesothelioma patient wants to benefit from immunotherapy they must participate in relevant clinical trials.

Bello kamorudeen.For more information on mesothelioma treatment visit http://www.mesotheliomacorner.blogspot.com